People with disabilities are a very heterogeneous group of people, which means that the process of rehabilitation varies from person to person. There are several techniques and methods for accepting and coping with one’s own disability and overcoming obstacles in the daily life of a disabled person. In my master's thesis I focus on supporting the rehabilitation of people with physical disabilities by participating in dramatic activities. In the theoretical introduction, I first introduce and explain some of the most important concepts in relation to physical disability. In addition to the field of special and rehabilitation pedagogy, which deals with persons with physical disabilities, the theoretical part also presents the field of assistance with dramatic activities. Due to the differentiation of terminology, I narrowly define stand-up comedy as a specific activity of applied theater, which promotes spontaneity and flexibility in an individual's behavior through humor, and thus influences resilience in facing life's challenges. In the empirical part of this master's thesis, I present the findings of the case studies I conducted. I interviewed and studied three adults with mobility impairments, who are active in the field of stand-up comedy. The main objective of my research is to investigate the role of stand-up as a supportive technique in the life and rehabilitation of adults with physical disabilities. The analysis of the conducted interviews clearly shows the importance and effectiveness of participating in dramatic activities. Survey participants confirmed that the positive effects of engaging in stand-up comedy are reflected in the quality of their lives, the co-creation of their self-image and self-esteem. In addition, I have outlined and demonstrated through the research the fact that disabled comedians raise awareness about physical disability and the problematic attitude of society among the general public, and consequently reduce stigma.