Introduction: Rehabilitation after upper limb amputation consists of activities to maximize amputees’ independence in performing activities of daily living. This includes testing devices for greater independence in home environment, testing and fabrication of suitable prosthesis for the missing limb, learning how to attach and use the prosthesis as a limb replacement. Purpose: The aim of scientific sources overview was to determine what are the research findings on treatment of patients following upper limb amputation. Methods: We used the descriptive method, reviewing domestic and foreign professional and scientific literature. The literature was obtained from online bibliographic databases, and from journals and proceedings both in print and online editions. Results: Rehabilitation after upper limb amputation should begin before the amputation itself, if the amputation is planned, or immediately after, if it is not planned, and then continues until complete reintegration into society. The goal of rehabilitation after limb amputation is to achieve similar psychophysical and social conditions prior to the amputation, which depends on the patient’s collaboration, cause and level of limb amputation, and accompanying medical conditions. Prostheses still cannot restore all functions of a human hand. Discussion and conclusion: Rehabilitation after upper limb amputation focuses on team treatment approach. Occupational therapist is an important member of the team and interacts with the recipient during all stages of rehabilitation. The first stage focuses on psychotherapeutic support, pain relief and stump care. Later in the process, they co-decide on prosthesis for the amputee, training attaching and using it in activities of daily living. The technology of prostheses manufacturing is constantly improving, but it will not replace the hand as an organ of expression and perception in the near future.