The aim of the thesis is to propose a renovation plan for an existing building located in a seismic prone area by assuring sufficient earthquake resistance of the superstructure and energy efficiency of the building. The main goal of the thesis is to present the measures of structural retrofitting and energetic renovation and to show how these measures can be used to increase of the building efficiency. In the first part, the thesis deals with an analysis of the building's earthquake resistance according to SIST EN 1998-3:2005 and an estimation of the building's energy efficiency according to Rules on efficient use of energy in buildings with a technical guideline and National plan for increasing the number of nearly zero-energy buildings. The second part contains a selection of measures of structural retrofitting and the energetic renovation of the building. The existing building is retrofitted by considering additional reinforced concrete walls along its perimeter. Energy efficiency is increased by using a method of bioclimatic design and several measures of passive solar architecture. The third part of the thesis includes analyses of how the selected measures impact the structural resistance and energy efficiency. This includes the verification of the new reinforced concrete walls as well as the elements of the existing structure that are regarded as secondary elements after the retrofitting. Additionally, the parameters of energy efficiency are controlled. The interaction between earthquake resistance and energy efficiency, and the reasonableness of renovation of existing buildings, taking into account safety (earthquake resistance) and sustainability (energy efficiency) aspects is emphasized.