Cisplatin is one of the most used cancer medicines, but its use is being limited by its toxicity. To mediate its side effects, we proposed the use of gallic acid. In this diploma thesis, we optimized the process for preparation of aromatic esters and used the aforementioned process for the preparation of gallic acid ester. This reaction served as an analogue for the addition of gallic acid to Pt(IV) complex as an axial ligand. Because of gallic acid’s poor solubility in organic solvents, we first acylated its OH groups and in this way increase its solubility. Both benzoic acid ester and gallic acid ester were prepared by first preparing acyl chloride derivatives of those acids. Acyl chlorides were prepared by using either oxalyl or thionyl chloride. Synthesized esters were confirmed by 1H NMR analysis.
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