Roll compaction is a simple and quick process of dry granulation that improves the physical, mechanical and/or chemical properties of the mixture. Due to the advancement in equipment and numerous advantages in terms of production costs and stability of products, it is becoming increasingly popular in the pharmaceutical industry. The effects of roller compaction process parameters (compaction force, roll speed, type of mill, screen size of sieve and surface of the screen) and the composition of ribbons (compactat) (different proportions of hypromellose with content of predominantly fragmenting or plastic filler) on the selected physical and mechanical properties of granulates and on the release of the active ingredient carvedilol from sustained release matrix tablets with hypromellose were studied in the present thesis. We have discovered that the composition of the mixture and the roller compaction process parameters can influence the particulate properties of the granules and that the influence of roller compaction process parameters depends on the mechanical properties of the materials. The influence of the particulate properties of granules is also expressed in the release of carvedilol from matrix tablets with hypromellose, the release of carvedilol from matrix tablets is also affected by tablet force.