Introduction: Carpal tunnel syndrome belongs to the category of chronic skeletal-muscle damage caused by overloading of the envelopes and wrists. It is also called the syndrome excessive burden. It represents a set of signs and symptoms that are the result of a medial nervous compression within the carpal tunnel. We can treat it surgically and non-surgical. Non-surgical treatment is with orthoses, steroid therapy and ultrasound treatment. Surgical treatment is the opening of the carpal tunnel and the release of the nerve and the endoscopic release of the nerve in the carpal tunnel. For making orthosis is the most commonly used thermoplastic materials with low temperature. The materials are low temperature if their processing temperature is between 57 ° and 82 ° C.Purpose: The purpose of the seminar is to present the anatomy of the wrist, the carpal tunnel syndrome and treat the carpal tunnel with orthoses. I asked myself whether the orthoses with the metacarpofalangeale unit are better compared to neutral wrist orthoses in the treatment of carpal tunnel syndrome.Methods:In my graduation thesis, I used the discretionary method of work, a review of already existing literature of the wrist and carpal tunnel. I searched literature from books and internet articles. I helped my sey with ScienceDirect, Medline, PubMed, Google Scholar and Cobiss. Articles and books were mostly in english and some were also in slovene language. I focused on finding orthosis with metacarpophalangeal units and neutral wrist orthoses. Results: They compared two different orthosis for the wrist. Normal orthoses for wrists and orthoses with a metacaprophalangeal unit. In two studies, half of the patients performed sliding exercises next to the orthoses every day. Discussion and conclusion: At the neutral orthosis, the wrist was in a neutral position, and in the orthosis with the metacarpofalangeal unit, it was in a slight flexion, both in the wrist and in the metacarpofalangeal joints. Orthosis with the metacarpalphalangeal unit showed better results in reducing symptoms, pain and functional state compared to normal orthosis. Although regular orthosis has also shown an improvement in the symptoms, pain and functional state of the hand. However, gliding exercises did not affect the improvement. The main effect is that we begin to carry orthosis three months after the onset of symptoms were showed and that we wear them regularly.