Vaš brskalnik ne omogoča JavaScript!
JavaScript je nujen za pravilno delovanje teh spletnih strani. Omogočite JavaScript ali pa uporabite sodobnejši brskalnik.
Nacionalni portal odprte znanosti
Odprta znanost
DiKUL
slv
|
eng
Iskanje
Brskanje
Novo v RUL
Kaj je RUL
V številkah
Pomoč
Prijava
Injections to pregnant mice produce prenatal stress that affects aggressive behavior in their adult male offspring
ID
Ogrizek, Monika
(
Avtor
),
ID
Grgurevič, Neža
(
Avtor
),
ID
Snoj, Tomaž
(
Avtor
),
ID
Majdič, Gregor
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(748,43 KB)
MD5: A2BF780368C4DDE3519EB5C31E26D803
Galerija slik
Izvleček
Maternal stress could reprogram the developing fetal nervous system. A common target of maternal glucocorticoids is fetal neuro-endocrine axis. In the present study, pregnant mice were exposed to stress by injection and their male offspring were tested for sexual and aggressive behaviors in adult life. Three groups of pregnant mice were exposed to stress by sham syringe injection. The first group was injected on days 13, 14, and 15 p.c., the second group was injected on days 17 and 18 p.c., and the third group was injected daily from days 13 to 18 p.c. while control mice were not injected. Male offspring that were exposed to stress on days 13–18 p.c. and 17–18 p.c. were less aggressive and had lower blood testosterone levels in comparison to the control group. In male sexual behavior, there were no statistically significant differences between the groups. Body weight differed significantly with groups injected on days 13–18 p.c. and 13–15 p.c. having significantly higher body weight in adult life than the other two groups. After behavioral testing, brains were processed for immunohistochemical staining with antibodies against vasopressin (AVP) and calbindin (CALB). The expression of AVP and CALB in the lateral septum and in the preoptic area, respectively, did not differ between groups, suggesting that these two masculinization markers were not affected by prenatal stress. Present study therefore shows that even presumably mild and short prenatal stress weakens aggressive behavior of adult male mice, possibly due to reduced testosterone levels in blood.
Jezik:
Angleški jezik
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Recenzirani rokopis
Leto izida:
2018
Št. strani:
Str. 35-43
Številčenje:
Vol. 106
PID:
20.500.12556/RUL-105258
UDK:
636.09:612
ISSN pri članku:
0018-506X
DOI:
10.1016/j.yhbeh.2018.09.001
COBISS.SI-ID:
4662138
Datum objave v RUL:
21.03.2019
Število ogledov:
1325
Število prenosov:
549
Metapodatki:
Citiraj gradivo
Navadno besedilo
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Kopiraj citat
Objavi na:
Gradivo je del revije
Naslov:
Hormones and behavior
Skrajšan naslov:
Horm. behav.
Založnik:
Elsevier
ISSN:
0018-506X
COBISS.SI-ID:
805512
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:
15.11.2018
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
J7-7226
Naslov:
Vloga ventromedialnega jedra hipotalamusa pri zaznavanju glukoze v telesu
Podobna dela
Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:
Nazaj