The thesis deals with educational and emotionally adaptive deficits in specific brain disorders, agenesis of corpus callosum. Here is a case study of fifteen-year-old boy, with this specific disorder found in his brain. Proposals for more effective identification of disturbances or deficits, for identification of specific needs and strengths of persons with this disorder, are based on the results gained on the basis of several research methods. This work offers a proposal on how to create a profile of the characteristics of persons with disability of corpus callosum and how to choose effective approach to reducing the educational and emotionally adaptive deficits of subjects with agenesis of corpus callosum. The professional approach and the interdisciplinary team approach of all involved in the person’s rehabilitation are very important for the treatment itself.