Spletna aplikacija za ročno razgradnjo medicinskih slik

VOGRINEC, PRIMOŽ (author), Kos, Bor (mentor)

Membrana biološke celice izpostavljene dovolj velikemu električnemu polju postane prepustna za molekule, za katere drugače ni. Temu pojavu pravimo elektroporacija. Velik izziv predstavlja zagotavljanje ustrezne porazdelitve električnega polja v celotnem volumnu tumorja. Pozicije in trajektorije vstavitve elektrod izračunamo z zahtevnimi postopki numeričnega modeliranja, za katere je potrebno ustrezno tehnično predznanje. Ravno zaradi potrebnega tehničnega predznanja numeričnega modeliranja, katerega v večini primerov medicinsko osebje nima, smo razvili namensko spletno aplikacijo, ki medicinskemu osebju omogoča za pacienta prilagojeno načrtovanje zdravljenja brez neposredne pomoči inženirjev oziroma ustreznega tehničnega predznanja. Postopek je sestavljen iz obdelave medicinskih slik, avtomatske in ročne razgradnje le teh, numeričnega modeliranja in optimizacije rezultatov. Namen orodja je olajšati in povečati uporabo elektroporacije in elektrokemoterapije v medicini.

• Language: Slovenian
• Keywords: ročna razgradnja, medicinske slike, elektroporacija, namenska spletna aplikacija
• Work type: Undergraduate thesis
• Organization: FE - Faculty of Electrical Engineering
• Year: 2016
• PID: 20.500.12556/RUL-83809
• Publication date in RUL: 30.06.2016

Secondary language

• Language: English
• Title: Web application for manual image segmentation

Abstract

Biological cell membrane exposed to high enough electrical field becomes permeable to certain molecules that otherwise is not. This phenomenon is called electroporation. Biggest challenge is to ensure complete and sufficient coverage of entire tumor volume with high enough electric field. Positions and entry trajectories of electrodes are calculated with complex numerical calculations; extensive technical knowledge is needed. Medical staff usually do not have such technical knowledge and is not able to solve this mathematical calculation without assistance of an engineer. We decided to develop special tool, that enables medical staff to perform patient specific treatment planning without assistance of an engineer or extensive technical knowledge. Procedures are based on medical images processing, automatic and manual image segmentation, numerical modeling and optimization. Aim of all this it to simplify and increase the use of electroporation in medicine.

• Keywords: manual segmentation, medical images, electroporation, web application