MicroRNA polymorphisms in cancer : a literature analysis

Pipan, Veronika (author), Zorc, Minja (author), Kunej, Tanja (author)

Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) genes (miR-SNPs) have attracted increasing attention in recent years due to their involvement in the development of various types of cancer. Therefore, a systematic review on this topic was needed. From 55 scientific publications we collected 20 SNPs, which are located within 18 miRNA encoding genes and have been associated with 16 types of cancer. Among 20 miRNA gene polymorphisms 13 are located within the premature miRNA region, five within mature, and two within mature seed miRNA region. We graphically visualized a network of miRNA-cancer associations which revealed miRNA genes and cancer types with the highest number of connections. Our study showed that, despite a large number of variations currently known to be located within miRNA genes in humans, most of them have not yet been tested for association with cancer. MicroRNA SNPs collected in this study represent only 0.43% of known miRNA gene variations (20/4687). Results of the present study will be useful to researchers investigating the clinical use of miRNAs, such as the roles of miRNAs as diagnostic markers and therapeutic targets.

• Language: English
• Keywords: microRNA (miRNA), cancer, single nucleotide polymorphisms (SNP)
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2015
• Number of pages: Str. 1806-1814
• Numbering: Vol. 7, iss. 3
• PID: 20.500.12556/RUL-82543
• UDC: 575:616
• ISSN on article: 2072-6694
• DOI: 10.3390/cancers7030863
• COBISS.SI-ID: 3609992
• Publication date in RUL: 25.05.2016

Record is a part of a journal

• Title: Cancers
• Shortened title: Cancers
• Publisher: MDPI
• ISSN: 2072-6694
• COBISS.SI-ID: 517914137

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 09.09.2015

Secondary language

• Language: Slovenian
• Keywords: molekularna genetika, mikro RNK, polimorfizem, medicina, rak

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0220
• Name: Primerjalna genomika in genomska biodiverziteta

• Funder: ARRS - Slovenian Research Agency
• Project number: Z4-6807
• Name: Razvoj bioinformacijskih orodij za odkrivanje genetskih biooznačevalcev za nalaganje maščobe pri sesalcih