20.500.12556/RUL-82543 MicroRNA polymorphisms in cancer a literature analysis Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) genes (miR-SNPs) have attracted increasing attention in recent years due to their involvement in the development of various types of cancer. Therefore, a systematic review on this topic was needed. From 55 scientific publications we collected 20 SNPs, which are located within 18 miRNA encoding genes and have been associated with 16 types of cancer. Among 20 miRNA gene polymorphisms 13 are located within the premature miRNA region, five within mature, and two within mature seed miRNA region. We graphically visualized a network of miRNA-cancer associations which revealed miRNA genes and cancer types with the highest number of connections. Our study showed that, despite a large number of variations currently known to be located within miRNA genes in humans, most of them have not yet been tested for association with cancer. MicroRNA SNPs collected in this study represent only 0.43% of known miRNA gene variations (20/4687). Results of the present study will be useful to researchers investigating the clinical use of miRNAs, such as the roles of miRNAs as diagnostic markers and therapeutic targets. microRNA (miRNA) cancer single nucleotide polymorphisms (SNP) molekularna genetika mikro RNK polimorfizem medicina rak true false true Angleški jezik Slovenski jezik Članek v reviji 2016-05-11 03:58:28 2016-05-25 11:52:33 2022-08-01 22:37:03 0000-00-00 00:00:00 2015 0 0 Str. 1806-1814 iss. 3 Vol. 7 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 575:616 2072-6694 10.3390/cancers7030863 3609992 517914137 RAZ_Zorc_Minja_2015.pdf RAZ_Zorc_Minja_2015.pdf 1 01DA8BC29464E077E7535485499DAE76 4837e256be61c138f6e8dd44de3adb9d8388abf2e5fa3a5b925f173f6b14fff9 086686ae-15eb-11ec-a523-00155dcfd717 20.500.12556/rul/555b375a-ff48-45ac-aa2b-28dfd981c42a https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147538 https://www.mdpi.com/2072-6694/7/3/863 0 ab045793-15ea-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147537 Biotehniška fakulteta 0 0 0