A review article presents an overview of national and international scientific literature about the use of information and communication technology (ICT) in schools, with an emphasis on chemistry education. The literature review has an emphasis on teachers and their role in the effective integration of ICT in teaching. It was found that it is crucial for successful learning process, that teachers combine their subject knowledge with the knowledge of pedagogy and technology (TPAC model). The literature review also confirmed that it`s essential for teachers to have supportive school environment, which through appropriate ICT infrastructure and equipment provides conditions for the use of ICT. However, the review of scientific literature also showed that the key factor for a successful integration of ICT in teaching is teachers` interest and their belief that the integration of ICT in the teaching has an added value in terms of improving the quality of the learning process. The integration of ICT in teaching in the future may accelerate the fact, that without the use of modern technology, teachers will not be able to achieve contemporary learning objectives, which will also be externally reviewed.The article in particular focused on the characteristics chemistry education, in terms of which, it presents some opportunities and challenges for chemistry teachers. In the end of the article, a model for successful integration of ICT in teaching is proposed. The model consists of the synthesis of the determinant factors, which on the one hand enable the identification of opportunities, and on the other a successful addressing of the challenges an information age.