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Ecotoxicologically relevant cyclic peptides from cyanobacterial bloom (Planktothrix rubecens) - a threat to human and environmental health
Sedmak, Bojan (Avtor), Eleršek, Tina (Avtor), Grach-Pogrebinsky, Olga (Avtor), Carmeli, Shmuel (Avtor), Sever, Nataša (Avtor), Lah Turnšek, Tamara (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.dlib.si/details/URN:NBN:SI:doc-I5AOW6B1 Povezava se odpre v novem oknu

Izvleček
Background. The information of the overall production of major cyanobacterial cyclic peptides in a water body is essential for risk assessment and for the prediction of future development of the bloom. A procedure that gives a reviewof both toxic and non-hepatotoxic hydrophilic cyclic peptide production is important to evaluate the ecological conditions in the water environment and to predict the release of dangerous toxic and tumour promoting substances.Methods. The cyclic peptides were identified on the basis of their retention times, characteristic spectra, molecular masses and biological activity. The non-hepatotoxic cyclic peptides were characterised by their inhibition of porcine pancreatic elastase, while cytotoxicity to mammalian cells was tested with the MTT test on B16 cell line. Conclusions. The method presented gives a rapid, simultaneous assessment, preliminary identification and estimation of bioactive cyclic peptides. The synthesis of non-hepatotoxic cyclic peptides can mediate the release various toxic and otherwise biologically active substances that induce systemic genotoxicity in mammals.

Jezik:Angleški jezik
Ključne besede:tumor promoters, microcystin, anabaenopeptin, planktopeptin, toxic cyanobacterial blooms, environmental health
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Leto izida:2008
Založnik:Croatian Medical Association - Croatian Society of Radiology
Št. strani:str. 102-113
Številčenje:Vol. 42, no 2
UDK:577
ISSN pri članku:1318-2099
DOI:10.2478/v10019-088-0001-9 Povezava se odpre v novem oknu
COBISS.SI-ID:1861199 Povezava se odpre v novem oknu
Število ogledov:367
Število prenosov:189
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:Ekotoksikološko pomembni ciklični peptidi iz cianobakterijskega cveta (Planktothrix rubescens) - grožnja človeškemu in okoljskemu zdravju

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