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Interaction between dipolar lipid headgroups and charged nanoparticles mediated by water dipoles and ions
ID Velikonja, Aljaž (Author), ID Budime Santhosh, Poornima (Author), ID Gongadze, Ekaterina (Author), ID Kulkarni, Mukta Vishwanath (Author), ID Eleršič Filipič, Kristina (Author), ID Perutková, Šárka (Author), ID Kralj-Iglič, Veronika (Author), ID Poklar Ulrih, Nataša (Author), ID Iglič, Aleš (Author)

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MD5: E1260405EEE8080DAFAF12DD159AAAE6
PID: 20.500.12556/rul/1ee92dc5-b35a-45b7-a709-18be48ce779e
URLURL - Source URL, Visit http://www.mdpi.com/1422-0067/14/8/15312 This link opens in a new window

Abstract
In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid headgroups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negatively charged nanoparticle, the headgroups are more extended. This result coincides with the calculated increase in the osmotic pressure between the zwitterionic lipid surface and positively charged nanoparticle and the decrease of osmotic pressure between the zwitterionic lipid surface and the negatively charged nanoparticle. Our theoretical predictions agree well with the experimentally determined fluidity of a lipid bilayer membrane in contact with positively or negatively charged nanoparticles. The prospective significance of the present work is mainly to contribute to better understanding of the interactions of charged nanoparticles with a zwitterionic lipid bilayer, which may be important in the efficient design of the lipid/nanoparticle nanostructures (like liposomes with encapsulated nanoparticles), which have diverse biomedical applications, including targeted therapy (drug delivery) and imaging of cancer cells.

Language:English
Keywords:charged nanoparticles, lipids, osmotic pressure, dipolar zwitterionic headgroups, relative permittivity of water, orientational ordering
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:BF - Biotechnical Faculty
FE - Faculty of Electrical Engineering
MF - Faculty of Medicine
ZF - Faculty of Health Sciences
Publication status:Published
Publication version:Version of Record
Year:2013
Number of pages:Str. 15312-15329
Numbering:Vol. 14, iss. 8
PID:20.500.12556/RUL-49107 This link opens in a new window
UDC:577.352:576.314
ISSN on article:1422-0067
DOI:10.3390/ijms140815312  This link opens in a new window
COBISS.SI-ID:4257144 This link opens in a new window
Publication date in RUL:10.07.2015
Views:1587
Downloads:403
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Record is a part of a journal

Title:International journal of molecular sciences
Shortened title:Int. j. mol. sci.
Publisher:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 This link opens in a new window

Licences

License:CC BY 3.0, Creative Commons Attribution 3.0 Unported
Link:https://creativecommons.org/licenses/by/3.0/deed.en
Description:You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Licensing start date:01.08.2013

Secondary language

Language:Slovenian
Keywords:biološke membrane, biofizika membrane, lipidi, nanodelci, elektrostatske interakcije

Projects

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije

Funder:EC - European Commission
Funding programme:European Social Fund

Funder:Drugi - Drug financer ali več financerjev
Funding programme:SMARTEH

Funder:Drugi - Drug financer ali več financerjev
Funding programme:Slovenian Human Resources Development and Scholarship Fund

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