Interaction between dipolar lipid headgroups and charged nanoparticles mediated by water dipoles and ions

Velikonja, Aljaž (author), Budime Santhosh, Poornima (author), Gongadze, Ekaterina (author), Kulkarni, Mukta Vishwanath (author), Eleršič Filipič, Kristina (author), Perutková, Šárka (author), Kralj-Iglič, Veronika (author), Poklar Ulrih, Nataša (author), Iglič, Aleš (author)

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid headgroups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negatively charged nanoparticle, the headgroups are more extended. This result coincides with the calculated increase in the osmotic pressure between the zwitterionic lipid surface and positively charged nanoparticle and the decrease of osmotic pressure between the zwitterionic lipid surface and the negatively charged nanoparticle. Our theoretical predictions agree well with the experimentally determined fluidity of a lipid bilayer membrane in contact with positively or negatively charged nanoparticles. The prospective significance of the present work is mainly to contribute to better understanding of the interactions of charged nanoparticles with a zwitterionic lipid bilayer, which may be important in the efficient design of the lipid/nanoparticle nanostructures (like liposomes with encapsulated nanoparticles), which have diverse biomedical applications, including targeted therapy (drug delivery) and imaging of cancer cells.

• Language: English
• Keywords: charged nanoparticles, lipids, osmotic pressure, dipolar zwitterionic headgroups, relative permittivity of water, orientational ordering
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: BF - Biotechnical Faculty; FE - Faculty of Electrical Engineering; MF - Faculty of Medicine; ZF - Faculty of Health Sciences
• Publication status: Published
• Publication version: Version of Record
• Year: 2013
• Number of pages: Str. 15312-15329
• Numbering: Vol. 14, iss. 8
• PID: 20.500.12556/RUL-49107
• UDC: 577.352:576.314
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms140815312
• COBISS.SI-ID: 4257144
• Publication date in RUL: 10.07.2015

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 3.0, Creative Commons Attribution 3.0 Unported
• Link: https://creativecommons.org/licenses/by/3.0/deed.en
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
• Licensing start date: 01.08.2013

Secondary language

• Language: Slovenian
• Keywords: biološke membrane, biofizika membrane, lipidi, nanodelci, elektrostatske interakcije