Interaction between dipolar lipid headgroups and charged nanoparticles mediated by water dipoles and ions

Velikonja, Aljaž (avtor), Budime Santhosh, Poornima (avtor), Gongadze, Ekaterina (avtor), Kulkarni, Mukta Vishwanath (avtor), Eleršič Filipič, Kristina (avtor), Perutková, Šárka (avtor), Kralj-Iglič, Veronika (avtor), Poklar Ulrih, Nataša (avtor), Iglič, Aleš (avtor)

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid headgroups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negatively charged nanoparticle, the headgroups are more extended. This result coincides with the calculated increase in the osmotic pressure between the zwitterionic lipid surface and positively charged nanoparticle and the decrease of osmotic pressure between the zwitterionic lipid surface and the negatively charged nanoparticle. Our theoretical predictions agree well with the experimentally determined fluidity of a lipid bilayer membrane in contact with positively or negatively charged nanoparticles. The prospective significance of the present work is mainly to contribute to better understanding of the interactions of charged nanoparticles with a zwitterionic lipid bilayer, which may be important in the efficient design of the lipid/nanoparticle nanostructures (like liposomes with encapsulated nanoparticles), which have diverse biomedical applications, including targeted therapy (drug delivery) and imaging of cancer cells.

• Jezik: Angleški jezik
• Ključne besede: charged nanoparticles, lipids, osmotic pressure, dipolar zwitterionic headgroups, relative permittivity of water, orientational ordering
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta ; FE - Fakulteta za elektrotehniko; MF - Medicinska fakulteta ; ZF - Zdravstvena fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2013
• Št. strani: Str. 15312-15329
• Številčenje: Vol. 14, iss. 8
• PID: 20.500.12556/RUL-49107
• UDK: 577.352:576.314
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms140815312
• COBISS.SI-ID: 4257144
• Datum objave v RUL: 10.07.2015

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 3.0, Creative Commons Priznanje avtorstva 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by/3.0/deed.sl
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• Začetek licenciranja: 01.08.2013

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: biološke membrane, biofizika membrane, lipidi, nanodelci, elektrostatske interakcije