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Inference of genotype probabilities and derived statistics for PrP locus in the Jezersko-Solcava sheep
Gorjanc, Gregor (Avtor), Kovač, Milena (Avtor), Kompan, Drago (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://dx.doi.org/10.1016/j.livsci.2010.01.002 Novo okno

Izvleček
The aim of this work was to infer PrP genotype probabilities and derived statistics in sheep in provide additional information for selection against susceptibility to classical scrapie. The method was demonstrated with data from Jezersko-Solcava breed. Pedigree data consisted of 10429 animals of which 3669 animals had known PrP genotype and 2673 were alive and not genotyped. Five PrP alleles were present with the following frequencies: ARR 0.174, AHQ 0.074, ARH 0.083, ARQ 0.632, and VRQ 0.037. Iterative allelic peeling with incomplete penetrace model as implemented in the GenoProb program was used to infer genotype probabilities. There were only some additional identifications of PrP genotype and NSP (national scrapie plan) type with high probability. The main reasons for a low number of additional identifications can be attributed to the large number of alleles with moderate frequencies, incomplete penetrace model, uniform prior, and inherent pedigree and genotype data structure. In order to overcome the limits of additional genotype identifications novel statistics were derived (maximal NSP type, average NSP value its variance and reliability)to facilitate practical implementation of seection for csrapie resistance based on NSP types. Maximal NSP type can be used to infer maximal potential scrapie susceptibility of individual animals as well as for the entire flocks. the average NSP value encompasses all information contained in PrP genotype probabilities and its the most useful dtatistic for the selection on NSP type and tehrefore PrP genotype. These novel statistics can be used as a criterion for the selection against scrapie susceptibility fot the whole population taking into the account possible errors in genotype and/or pedigree data.

Jezik:Angleški jezik
Ključne besede:ovce, pasme, jezersko-solčavska ovca, praskavec, genetika, lokus PrP, genotipi, statistika
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Leto izida:2010
Št. strani:str. 232-236
Številčenje:Vol. 129, no. 2/3
UDK:636.3:575
ISSN pri članku:1871-1413
DOI:10.1016/j.livsci.2010.01.002 Povezava se odpre v novem oknu
COBISS.SI-ID:2571400 Povezava se odpre v novem oknu
Število ogledov:577
Število prenosov:149
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Livestock science
Skrajšan naslov:Livest. sci.
Založnik:Elsevier
ISSN:1871-1413
COBISS.SI-ID:2031496 Novo okno

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