Statin adherence in atherosclerotic disease : research data underlying the article

Furlan, Tjaša (author), Došenović Bonča, Petra (author), Ograjenšek, Irena (author), Jug, Borut (author)

Aims: To evaluate post-discharge statin adherence and its association with clinical outcomes after hospitalisation for atherosclerotic cardiovascular disease (ASCVD). Methods: In this nationwide Slovenian cohort, hospital, pharmacy, and vital-status data were linked for adults hospitalised with coronary artery, cerebrovascular, or peripheral artery disease between 2015 and 2022. Statin adherence was assessed as time-varying rolling 365-day proportion of days covered (PDC) and 120-day CMA7. The outcome was all-cause death or rehospitalisation for ASCVD. Results: Of 82,083 patients in the 30-day landmark cohort, 62,932 had at least one post-discharge statin dispensing. Overall, 23% had no recorded post-discharge dispensing, rising to 30% in peripheral artery disease. Higher adherence was independently associated with lower risk of the composite outcome: each 10-percentage-point increase in PDC and CMA7 was associated with a hazard ratio of 0.96 (95% CI 0.96–0.97; both p<0.001). Conclusion: Better longitudinal statin adherence was associated with lower risk of death or recurrent ASCVD hospitalisation, while substantial treatment gaps remained, particularly in peripheral artery disease.

• Language: English
• Keywords: atherosclerotic cardiovascular disease, statins, medication adherence, persistence, secondary prevention
• Typology: 2.20 - Complete scientific database of research data
• Geographic coverage: Slovenia
• Temporal coverage: 2015-2022
• Organization: MF - Faculty of Medicine
• Year: 2026
• PID: 20.500.12556/RUL-186851
• Data col. methods: Synthesis; Aggregation; Other
• Publication date in RUL: 10.09.2026

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: aterosklerotična srčno-žilna bolezen, statini, adherenca k zdravljenju z zdravili, vztrajnost pri zdravljenju, sekundarna preventiva

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: V3-24038
• Name: Strokovna izhodišča in priporočila za oblikovanje državnega programa obvladovanja bolezni srca in ožilja v Sloveniji

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P5-0117
• Name: Trajnostna konkurenčnost slovenskega gospodarstva v evropskem in globalnem okviru