Antioxidant and neurodevelopmental gene polymorphisms in prematurely born individuals influence hypoxia-related oxidative stress

Goričar, Katja (author), Debevec, Tadej (author), Dolžan, Vita (author), Martin, Agnès (author), Pialoux, Vincent (author), Millet, Grégoire P. (author), Osredkar, Damjan (author)

Preterm born (PTB) infants are at risk for injuries related to oxidative stress. We investigated the association between antioxidant and neurodevelopmental gene polymorphisms and oxidative stress parameters in PTB male young adults and their term-born counterparts at rest and during exercise. Healthy young PTB (N= 22) and full-term (N= 15) males underwent graded exercise tests in normobaric normoxic (F$_i$O$_2$ = 0.21) and hypoxic (F$_i$O$_2$ = 0.13) conditions. CAT rs1001179 was associated with decrease in nitrites in the whole group and in PTB individuals (P= 0.017 and P= 0.043, respectively). GPX1 rs1050450 was associated with decrease in ferric reducing antioxidant power in the whole group and in full-term individuals (P= 0.017 and P= 0.021, respectively). HIF1A rs11549465 was associated with decrease in nitrotyrosine and increase in malondialdehyde (P= 0.022 and P= 0.018, respectively). NOTCH4 rs367398 was associated with increase in advanced oxidation protein products and nitrites (P= 0.002 and P= 0.004, respectively) in hypoxia. In normoxia, NOTCH4 rs367398 was associated with increase in malondialdehyde in the whole group (P= 0.043). BDNF rs6265 was associated with decreased nitrites/nitrates in the whole group and in PTB individuals (P= 0.009 and P= 0.043, respectively). Polymorphisms in investigated genes and PTB might influence oxidative stress response after exercise in normoxic or hypoxic conditions far beyond the neonatal period in young male adults.

• Language: English
• Keywords: sport, antioxidant, neurodevelopmental gene, prematurely born individuals, hypoxia-related oxidative stress
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FŠ - Faculty of Sport; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 10 str.
• Numbering: Vol. 14, art. 14956
• PID: 20.500.12556/RUL-186627
• UDC: 796:616.12-008.44
• ISSN on article: 2045-2322
• DOI: 10.1038/s41598-024-65647-4
• COBISS.SI-ID: 200453379
• Publication date in RUL: 03.09.2026

Record is a part of a journal

• Title: Scientific reports
• Shortened title: Sci. rep.
• Publisher: Springer Nature
• ISSN: 2045-2322
• COBISS.SI-ID: 18727432

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: šport, antioksidanti, nevrorazvojni gen, prezgodaj rojeni, hipoksija, oksidativni stres