20.500.12556/RUL-186627 Antioxidant and neurodevelopmental gene polymorphisms in prematurely born individuals influence hypoxia-related oxidative stress Preterm born (PTB) infants are at risk for injuries related to oxidative stress. We investigated the association between antioxidant and neurodevelopmental gene polymorphisms and oxidative stress parameters in PTB male young adults and their term-born counterparts at rest and during exercise. Healthy young PTB (N= 22) and full-term (N= 15) males underwent graded exercise tests in normobaric normoxic (F$_i$O$_2$ = 0.21) and hypoxic (F$_i$O$_2$ = 0.13) conditions. CAT rs1001179 was associated with decrease in nitrites in the whole group and in PTB individuals (P= 0.017 and P= 0.043, respectively). GPX1 rs1050450 was associated with decrease in ferric reducing antioxidant power in the whole group and in full-term individuals (P= 0.017 and P= 0.021, respectively). HIF1A rs11549465 was associated with decrease in nitrotyrosine and increase in malondialdehyde (P= 0.022 and P= 0.018, respectively). NOTCH4 rs367398 was associated with increase in advanced oxidation protein products and nitrites (P= 0.002 and P= 0.004, respectively) in hypoxia. In normoxia, NOTCH4 rs367398 was associated with increase in malondialdehyde in the whole group (P= 0.043). BDNF rs6265 was associated with decreased nitrites/nitrates in the whole group and in PTB individuals (P= 0.009 and P= 0.043, respectively). Polymorphisms in investigated genes and PTB might influence oxidative stress response after exercise in normoxic or hypoxic conditions far beyond the neonatal period in young male adults. sport antioxidant neurodevelopmental gene prematurely born individuals hypoxia-related oxidative stress šport antioksidanti nevrorazvojni gen prezgodaj rojeni hipoksija oksidativni stres true false true Angleški jezik Slovenski jezik Članek v reviji 2026-09-03 14:02:27 2026-09-03 14:02:28 2026-09-05 03:32:38 0000-00-00 00:00:00 2024 0 0 10 str. art. 14956 Vol. 14 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 796:616.12-008.44 2045-2322 10.1038/s41598-024-65647-4 200453379 s41598-024-65647-4.pdf s41598-024-65647-4.pdf 1 08E7B53831F5CC0B9F904DF944B9BAC8 59b7909fe9f630362ffc94795b0217b3b60251151da146c206e9898a6bd01025 70f1766d-a790-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=245917 https://www.nature.com/articles/s41598-024-65647-4 1 5913fd96-a78f-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=245915 Fakulteta za šport Medicinska fakulteta 0 0 0