Chromatic visual evoked potentials : a review of physiology, methods and clinical applications

Marmoy, Oliver R. (author), Tekavčič Pompe, Manca (author), Kremers, Jan (author)

Objective assessment of the visual system can be performed electrophysiologically using the visual evoked potential (VEP). In many clinical circumstances, this is performed using high contrast achromatic patterns or diffuse flash stimuli. These methods are clinically valuable but they may only assess a subset of possible physiological circuitries within the visual system, particularly those involved in achromatic (luminance) processing. The use of chromatic VEPs (cVEPs) in addition to standard VEPs can inform us of the function or dysfunction of chromatic pathways. The chromatic VEP has been well studied in human health and disease. Yet, to date our knowledge of their underlying mechanisms and applications remains limited. This likely reflects a heterogeneity in the methodology, analysis and conclusions of different works, which leads to ambiguity in their clinical use. This review sought to identify the primary methodologies employed for recording cVEPs. Furthermore cVEP maturation and application in understanding the function of the chromatic system under healthy and diseased conditions are reviewed. We first briefly describe the physiology of normal colour vision, before describing the methodologies and historical developments which have led to our understanding of cVEPs. We thereafter describe the expected maturation of the cVEP, followed by reviewing their application in several disorders: congenital colour vision deficiencies, retinal disease, glaucoma, optic nerve and neurological disorders, diabetes, amblyopia and dyslexia. We finalise the review with recommendations for testing and future directions.

• Language: English
• Keywords: chromatic, chromatic VEP, colo*r, electrophysiology, VEP, visual evoked potentials
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 24 str.
• Numbering: Vol. 101, art. 101272
• PID: 20.500.12556/RUL-182658
• UDC: 617.7
• ISSN on article: 1873-1635
• DOI: 10.1016/j.preteyeres.2024.101272
• COBISS.SI-ID: 197909251
• Publication date in RUL: 20.05.2026

Record is a part of a journal

• Title: Progress in Retinal and Eye Research
• Publisher: Elsevier
• COBISS.SI-ID: 23036421

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Undetermined
• Keywords: kromatsko, kromatsko VEP, barva, elektrofiziologija, vizualno evocirani potenciali