Hair conditioners represent an indispensable part of cosmetic care aimed at improving the structure, appearance, and health of the hair. Their primary function is to provide adequate hydration, reduce damage caused by mechanical and chemical influences, and facilitate combing. With growing interest in hair care and the development of innovative formulations, conditioners have become a key product in the daily routine of many individuals.
This Master's thesis presents a toxicological safety assessment of a cosmetic product – a hair conditioner – in accordance with Regulation (EC) No. 1223/2009 and the guidelines of the Scientific Committee on Consumer Safety (SCCS). The main objective of the research was to evaluate the safety of individual ingredients in the product, taking into account their concentration in the formulation, estimated dermal absorption, systemic exposure dose (SED), and available data on the No Observed Adverse Effect Level (NOAEL).
The thesis also outlines the basic principles of toxicological assessment, the structure of the cosmetic product safety report, and the legislative framework. Thus, it provides a comprehensive insight into the practical implementation of safety assessment and the role of the qualified safety assessor in ensuring product compliance on the market.
For all ingredients, basic physicochemical properties, toxicological profiles, and other relevant data (including dermal absorption and NOAEL values) were collected from scientific literature and regulatory sources. The Margin of Safety (MoS) approach was used for risk assessment, and it was determined that all ingredients included in the formulation exceed the safety threshold of MoS ≥ 100, indicating that the product is safe for use under the intended conditions.
The calculations performed confirm that the hair conditioner under consideration is safe for consumers when used as intended and is fully compliant with the requirements of current European cosmetic legislation.
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