Ex vivo electrophysiological evaluation of peripheral nerve functioning following exposition of adult mice to the organophosphorus pesticide chlormephos

Frangež, Robert (author), Benoit, Evelyne (author)

The organophosphorus pesticide chlormephos was tested for its potential peripheral neurotoxicity by analyzing the diphasic compound action potential (CAP) of sciatic nerves isolated from adult mice chronically exposed to a sub-lethal dose of this pesticide, compared with control age-matched animals being only exposed to the vehicle. No significant modification was detected between chlormephos-exposed and control groups in their nerve responsiveness to stimulus. Furthermore, similar values of CAP kinetic variables were obtained from the two mouse groups. Finally, no abnormality concerning CAP refractory periods and responsiveness to high frequency stimulation (nerve fatigue) was exhibited by chlormephos-treated mice, when compared with control animals. These results complicate the screening for the potential neurotoxicity of organophosphates since they support the contention that the peripheral neuropathy induced by chronical exposition to sub-lethal doses of chlormephos is species dependents does not necessary correlate well with the clinical signs observed at the central nervous system level.

• Language: English
• Keywords: chlormephos, organophosphorus pesticide, chronical oral administration, mouse sciatic nerve, diphasic compound action potential, ex vivo electrophysiology
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: 7 str.
• Numbering: Vol. 114, art. 104645
• PID: 20.500.12556/RUL-166930
• UDC: 591:636.09
• ISSN on article: 1872-7077
• DOI: 10.1016/j.etap.2025.104645
• COBISS.SI-ID: 224130563
• Publication date in RUL: 31.01.2025

Record is a part of a journal

• Title: Environmental toxicology and pharmacology
• Publisher: ElsevierBV
• ISSN: 1872-7077
• COBISS.SI-ID: 175280899

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P4-0053
• Name: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

• Funder: Other - Other funder or multiple funders
• Funding programme: Bilateral Slovenian/French Proteus Program
• Project number: BI-FR-21-22-PROTEUS-002/46143VH