20.500.12556/RUL-166930 Ex vivo electrophysiological evaluation of peripheral nerve functioning following exposition of adult mice to the organophosphorus pesticide chlormephos The organophosphorus pesticide chlormephos was tested for its potential peripheral neurotoxicity by analyzing the diphasic compound action potential (CAP) of sciatic nerves isolated from adult mice chronically exposed to a sub-lethal dose of this pesticide, compared with control age-matched animals being only exposed to the vehicle. No significant modification was detected between chlormephos-exposed and control groups in their nerve responsiveness to stimulus. Furthermore, similar values of CAP kinetic variables were obtained from the two mouse groups. Finally, no abnormality concerning CAP refractory periods and responsiveness to high frequency stimulation (nerve fatigue) was exhibited by chlormephos-treated mice, when compared with control animals. These results complicate the screening for the potential neurotoxicity of organophosphates since they support the contention that the peripheral neuropathy induced by chronical exposition to sub-lethal doses of chlormephos is species dependents does not necessary correlate well with the clinical signs observed at the central nervous system level. chlormephos organophosphorus pesticide chronical oral administration mouse sciatic nerve diphasic compound action potential ex vivo electrophysiology true false true Angleški jezik Ni določen Članek v reviji 2025-01-31 09:28:06 2025-01-31 09:28:10 2025-02-01 04:06:26 0000-00-00 00:00:00 2025 0 0 7 str. Vol. 114, art. 104645 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 591:636.09 1872-7077 10.1016/j.etap.2025.104645 224130563 FRANGEZ_EX_VIVO_1-s2.0-S1382668925000201-main.pdf FRANGEZ_EX_VIVO_1-s2.0-S1382668925000201-main.pdf 1 E4BBCDB913E77877383878BC22653D6B badacd0aba7ca87a8f2080374c81de75fe045c688118117c81143253209f71a5 24277953-dfad-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=198993 https://www.sciencedirect.com/science/article/pii/S1382668925000201 1 7b9b06f5-dfac-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=198992 Veterinarska fakulteta 0 0 0