Introduction: Parkinson's disease is one of the most common progressive degenerative movement disorders caused by a lack of dopamine neurons. The disease manifests itself through various motor and non-motor symptoms that affect the occupational performance and the quality of life of persons with Parkinson's disease. Currently, there is only symptomatic treatment for Parkinson's disease, including deep brain stimulation. Purpose: The purpose of the diploma work was to review the literature on deep brain stimulation and to determine its effects on everyday functioning of patients with Parkinson's disease, their occupational performance and quality of life. Methods: A literature review was conducted. Based on the inclusion and exclusion criteria, the literature was searched in the databases Web of Science, CINAHL, Medline and OTseeker. A combination of English keywords and Boolean operators AND and OR was used for the search. The studies for the final analysis were selected according to the assessment of relevance, based on my own criteria, and were descriptively and thematically analyzed. Results: Twelve articles were included in the final analysis. The analyzed articles reached different levels of relevance and contained qualitative and quantitative evaluation methods. The findings were summarized in six themes that describe the effects of deep brain stimulation in people with Parkinson's disease on their quality of life, ccupational performance, motor and non-motor symptoms of the disease, the need for dopaminergic medications and what are the possible side effects of the treatment. Discussion and conclusion: The effects of deep brain stimulation in people with Parkinson's disease are visible in the long-term improvement of their quality of life, occupational performance and some motor and non-motor symptoms of the disease. Improvement in motor symptoms was most evident in the reduction of tremor, rigidity, bradykinesia, and drug-induced motor complications. Among the non-motor symptoms, the improvement was mainly noticeable in the reduction of pain and the improvement of mental health and sleep quality. Due to the improvement of motor and non-motor symptoms of the disease, occupational performance and engagement also improved for people with Parkinson's disease. After the treatment they became more independent in their daily lives and re-engaged in the occupations that they had to give up due to the disease before the treatment. The level of quality of life of people with Parkinson's disease has also increased. In addition to positive effects, negative side effects of deep brain stimulation have also been observed.
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