The conversion of sulfides to sulfoximines is a chemical process that involves the transformation of a sulfide (R-S-R) first into a sulfoxide (R-SO-R) and then into a sulfoximine (R-SO-NH-R). In organic synthesis, this step is important because it allows the preparation of compounds with a sulfoximine functional group, which are used in medicinal chemistry or as intermediates in the synthesis of other complex organic compounds.
Approaches to NH-sulfoximines are based on multi-step syntheses starting from sulfides. In this context, strategies are available for selective N- or O-transfer to the sulfur atom, leading to the corresponding sulfoxide or sulfilimide. This primarily involves directly preparing NH-sulfoximines using readily accessible ammonia sources in the presence of PhI(OAc)$_2$.
In my thesis, I focused on converting sulfides to sulfoximines, which I carried out with ammonium carbonate in the presence of (diacetoxyiodo)benzene in methanol, first on a small scale and then on a larger scale.
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