Toll-like receptor 10 (TLR10) is a receptor of the innate immune system that is unique among TLRs in that it is thought to have immunomodulatory potential. It was the last of the Toll-like receptors to be discovered and is still considered an orphan receptor, as its ligands and mechanisms of action are not yet fully understood. Previous research suggests that its mode of action is pro-inflammatory, but more recent studies report its anti-inflammatory effects. In this study, we investigated the effects of rs4129009 polymorphism and TLR10 knockout on the expression of inflammatory cytokines (CXCL10, IL-1β, IL-8 and TNF-α) in A549 lung epithelial cells immunostimulated with Pam3-Cys. The results confirm an immunomodulatory role of TLR10, as the expression of inflammatory cytokines was higher in the cells with the knocked out gene, compared to the cells with functional TLR10. The rs4129009 polymorphism attenuated the anti-inflammatory effect of TLR10, as it significantly reduced the inhibition of expression of the inflammatory CXCL10. In addition, a decrease in the expression of the other cytokines was observed, but the changes were not statistically significant.
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