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Experimental investigation and thermodynamic modelling of cannabidiol and curcumin in different solvents
ID
Tavčar, Eva
(
Author
),
ID
Vidak, Marko
(
Author
)
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MD5: 4FCAEDE3CEDC0D6B7577F085B659B268
URL - Source URL, Visit
https://www.sciencedirect.com/science/article/pii/S016773222401568X
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Abstract
Cannabidiol (CBD) and curcumin (CUR) are pharmacologically active substances whose therapeutic effect is limited due to their low water solubility. In this study, we investigated their solubility in different solvents experimentally using the shake flask method and in silico using the COSMO-RS software. We found that CBD is very soluble in DMSO, DMF, acetone, methanol, diethyl ether, isopropanol, ethanol, 1-butanol, PEG 400, triacetin, triethyl citrate, propylene glycol, hexane, isooctane and vegetable oils. CUR is very soluble in DMSO, DMF, acetone and PEG 400 and slightly soluble to insoluble in vegetable oils. The COSMO-RS method shows reasonable relative accuracy (measured as the absolute percentage error) for predicting the solubility of CBD and CUR in solvents in which these compounds are very soluble.
Language:
English
Keywords:
cannabidiol
,
curcumin
,
solubility
,
organic solvents
,
plant oils
,
COSMO-RS
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2024
Number of pages:
10 str.
Numbering:
Vol. 410, article no. 125511
PID:
20.500.12556/RUL-160068
UDC:
615.322:633.522
ISSN on article:
0167-7322
DOI:
10.1016/j.molliq.2024.125511
COBISS.SI-ID:
203694083
Publication date in RUL:
14.08.2024
Views:
52
Downloads:
1
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Record is a part of a journal
Title:
Journal of molecular liquids
Shortened title:
J. mol. liq.
Publisher:
Elsevier
ISSN:
0167-7322
COBISS.SI-ID:
15382277
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
kanabidiol
,
kurkumin
,
rastlinska olja
,
COSMO-RS
,
protivnetno delovanje
,
topnost
,
organska topila
,
kanabinoidi
Projects
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
P1-0208
Name:
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
P3-0296
Name:
Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci
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