Experimental investigation and thermodynamic modelling of cannabidiol and curcumin in different solvents

Tavčar, Eva (author), Vidak, Marko (author)

Cannabidiol (CBD) and curcumin (CUR) are pharmacologically active substances whose therapeutic effect is limited due to their low water solubility. In this study, we investigated their solubility in different solvents experimentally using the shake flask method and in silico using the COSMO-RS software. We found that CBD is very soluble in DMSO, DMF, acetone, methanol, diethyl ether, isopropanol, ethanol, 1-butanol, PEG 400, triacetin, triethyl citrate, propylene glycol, hexane, isooctane and vegetable oils. CUR is very soluble in DMSO, DMF, acetone and PEG 400 and slightly soluble to insoluble in vegetable oils. The COSMO-RS method shows reasonable relative accuracy (measured as the absolute percentage error) for predicting the solubility of CBD and CUR in solvents in which these compounds are very soluble.

• Language: English
• Keywords: cannabidiol, curcumin, solubility, organic solvents, plant oils, COSMO-RS
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 11 str.
• Numbering: Vol. 410, art. 125511
• PID: 20.500.12556/RUL-160068
• UDC: 615.322:633.522
• ISSN on article: 0167-7322
• DOI: 10.1016/j.molliq.2024.125511
• COBISS.SI-ID: 203694083
• Publication date in RUL: 14.08.2024

Record is a part of a journal

• Title: Journal of molecular liquids
• Shortened title: J. mol. liq.
• Publisher: Elsevier
• ISSN: 0167-7322
• COBISS.SI-ID: 15382277

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: kanabidiol, kurkumin, rastlinska olja, COSMO-RS, protivnetno delovanje, topnost, organska topila, kanabinoidi

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0208
• Name: Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P3-0296
• Name: Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci