20.500.12556/RUL-160068 Experimental investigation and thermodynamic modelling of cannabidiol and curcumin in different solvents Cannabidiol (CBD) and curcumin (CUR) are pharmacologically active substances whose therapeutic effect is limited due to their low water solubility. In this study, we investigated their solubility in different solvents experimentally using the shake flask method and in silico using the COSMO-RS software. We found that CBD is very soluble in DMSO, DMF, acetone, methanol, diethyl ether, isopropanol, ethanol, 1-butanol, PEG 400, triacetin, triethyl citrate, propylene glycol, hexane, isooctane and vegetable oils. CUR is very soluble in DMSO, DMF, acetone and PEG 400 and slightly soluble to insoluble in vegetable oils. The COSMO-RS method shows reasonable relative accuracy (measured as the absolute percentage error) for predicting the solubility of CBD and CUR in solvents in which these compounds are very soluble. cannabidiol curcumin solubility organic solvents plant oils COSMO-RS kanabidiol kurkumin rastlinska olja COSMO-RS protivnetno delovanje topnost organska topila kanabinoidi true false true Angleški jezik Slovenski jezik Članek v reviji 2024-08-14 12:43:53 2024-08-14 12:43:58 2024-08-23 12:47:34 0000-00-00 00:00:00 2024 0 0 11 str. Vol. 410, art. 125511 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.322:633.522 0167-7322 10.1016/j.molliq.2024.125511 203694083 1-s2.0-S016773222401568X-main.pdf 1-s2.0-S016773222401568X-main.pdf 1 4FCAEDE3CEDC0D6B7577F085B659B268 4962172e2ff089e59ebd12fa817f3f0280fbe4ca6431479503b526f2841a361d 45d2cfee-5a2a-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188503 https://www.sciencedirect.com/science/article/pii/S016773222401568X 1 efe6e877-5a29-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188502 Fakulteta za farmacijo Medicinska fakulteta 0 0 0