Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels

Palir, Neža (avtor), Marc, Janja (avtor), Falnoga, Ingrid (avtor)

Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ɛ2, ɛ3, ɛ4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay among maternal APOE (mAPOE) genotypes, fetal sex, parity, and Pb in maternal and cord blood (mB-Pb, CB-Pb) using linear regression models. Our study involved 817 pregnant women and 772 newborns with measured adequate levels of zinc and selenium. We compared carriers of the ε2 and ε4 alleles to those with the ε3/ε3 genotype. The geometric means (range) of mB-Pb and CB-Pb were 11.1 (3.58–87.6) and 9.31 (1.82–47.0) ng/g, respectively. In cases with female fetuses, the maternal mAPOE ε2 allele was associated with higher, while the mAPOE ε4 allele was associated with lower mB-Pb and CB-Pb levels. Nulliparity increased the strength of the observed associations. These findings highlight the significance of mAPOE genetics, fetal sex, and parity in prenatal Pb kinetics. Notably, the maternal ε2 allele may increase the risk of Pb exposure.

• Jezik: Angleški jezik
• Ključne besede: cord blood, maternal APOE ε2 allele, bone turnover, fetal sex, parity, lead, blood
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 12 str.
• Številčenje: Vol. 260, art. 119583
• PID: 20.500.12556/RUL-159802
• UDK: 504.5
• ISSN pri članku: 1096-0953
• DOI: 10.1016/j.envres.2024.119583
• COBISS.SI-ID: 202005507
• Datum objave v RUL: 25.07.2024

Gradivo je del revije

• Naslov: Environmental research
• Skrajšan naslov: Environ. res.
• Založnik: Elsevier
• ISSN: 1096-0953
• COBISS.SI-ID: 512760888

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: popkovna kri, plodov spol, polimorfizmi, svinec, kri, nosečnost, fetus

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0143
• Naslov: Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J7-9400
• Naslov: Nevropsihološke disfunkcije, ki jih povzroča nizka stopnja izpostavljenosti izbranim onesnaževalom iz okolja pri občutljivi populaciji - NEURODYS