The impact of phospholipid-based liquid crystals’ microstructure on stability and release profile of ascorbyl palmitate and skin performance

Zvonar Pobirk, Alenka (author), Roškar, Robert (author), Bešter-Rogač, Marija (author), Gašperlin, Mirjana (author), Gosenca Matjaž, Mirjam (author)

The drug delivery potential of liquid crystals (LCs) for ascorbyl palmitate (AP) was assessed, with the emphasis on the AP stability and release profile linked to microstructural rearrangement taking place along the dilution line being investigated by a set of complementary techniques. With high AP degradation observed after 56 days, two stabilization approaches, i.e., the addition of vitamin C or increasing AP concentration, were proposed. As a rule, LC samples with the lowest water content resulted in better AP stability (up to 52% of nondegraded AP in LC1 after 28 days) and faster API release (~18% in 8 h) as compared to the most diluted sample (29% of nondegraded AP in LC8 after 28 days, and up to 12% of AP released in 8 h). In addition, LCs exhibited a skin barrier-strengthening effect with up to 1.2-fold lower transepidermal water loss (TEWL) and 1.9-fold higher skin hydration observed in vitro on the porcine skin model. Although the latter cannot be linked to LCs’ composition or specific microstructure, the obtained insight into LCs’ microstructure contributed greatly to our understanding of AP positioning inside the system and its release profile, also influencing the overall LCs’ performance after dermal application.

• Language: English
• Keywords: lamellar liquid crystals, microstructure, ascorbyl palmitate, stability, skin delivery systems
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy; FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: Str. 1-20
• Numbering: Vol. 29, iss. 13, art. 3173
• PID: 20.500.12556/RUL-159210
• UDC: 544.25:615.015.14
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules29133173
• COBISS.SI-ID: 200578819
• Publication date in RUL: 03.07.2024

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: lamelarni tekoči kristali, mikrostruktura, askorbil palmitat, stabilnost, sistemi za dostavo kože, dostavni sistemi, tekoči kristali

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0189
• Name: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih