20.500.12556/RUL-159210 The impact of phospholipid-based liquid crystals’ microstructure on stability and release profile of ascorbyl palmitate and skin performance The drug delivery potential of liquid crystals (LCs) for ascorbyl palmitate (AP) was assessed, with the emphasis on the AP stability and release profile linked to microstructural rearrangement taking place along the dilution line being investigated by a set of complementary techniques. With high AP degradation observed after 56 days, two stabilization approaches, i.e., the addition of vitamin C or increasing AP concentration, were proposed. As a rule, LC samples with the lowest water content resulted in better AP stability (up to 52% of nondegraded AP in LC1 after 28 days) and faster API release (~18% in 8 h) as compared to the most diluted sample (29% of nondegraded AP in LC8 after 28 days, and up to 12% of AP released in 8 h). In addition, LCs exhibited a skin barrier-strengthening effect with up to 1.2-fold lower transepidermal water loss (TEWL) and 1.9-fold higher skin hydration observed in vitro on the porcine skin model. Although the latter cannot be linked to LCs’ composition or specific microstructure, the obtained insight into LCs’ microstructure contributed greatly to our understanding of AP positioning inside the system and its release profile, also influencing the overall LCs’ performance after dermal application. lamellar liquid crystals microstructure ascorbyl palmitate stability skin delivery systems lamelarni tekoči kristali mikrostruktura askorbil palmitat stabilnost sistemi za dostavo kože dostavni sistemi tekoči kristali true false true Angleški jezik Slovenski jezik Članek v reviji 2024-07-03 13:59:19 2024-07-03 13:59:23 2024-07-13 03:52:57 0000-00-00 00:00:00 2024 0 0 Str. 1-20 iss. 13, art. 3173 Vol. 29 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 544.25:615.015.14 1420-3049 10.3390/molecules29133173 200578819 molecules-29-03173.pdf molecules-29-03173.pdf 1 9920E662BA731BA27922F9FE4A96CCE4 fc7631b5a796a0de730dfd6b03d23ad658431b99097c9cc2b03e6d292d5f46b8 24b98c38-3934-11ef-a3da-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=187159 https://www.mdpi.com/1420-3049/29/13/3173 1 b004f147-3933-11ef-a3da-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=187158 Fakulteta za farmacijo Fakulteta za kemijo in kemijsko tehnologijo 0 0 0