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Men, testosterone and Covid‐19
ID
Groti Antonić, Kristina
(
Avtor
),
ID
Antonič, Blaž
(
Avtor
),
ID
Caliber, Monica
(
Avtor
),
ID
Dhindsa, Sandeep
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(621,64 KB)
MD5: A90C92F58D0B3322293E4BB84D0FC396
URL - Izvorni URL, za dostop obiščite
https://onlinelibrary.wiley.com/doi/10.1111/cen.14952
Galerija slik
Izvleček
Men have more severe Coronavirus disease 2019 (Covid‐19) outcomes and higher mortality rates than women, and it was suggested that testosterone levels might promote severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and Covid‐19 severity. However, clinical studies have not supported this theory. Studies have consistently shown that serum testosterone concentrations during acute Covid‐19 in men are inversely proportional to the inflammatory cytokines and severity of illness. It is likely that lower testosterone concentrations in this setting are a result of acute Covid‐19 illness on the hypothalamic–pituitary–testicular axis. Clinical trials that attempted to lower testosterone concentrations further or block androgen signaling acutely during Covid‐19 in men did not result in improved Covid‐19 outcomes. Additionally, pre‐existing male hypogonadism, diagnosed before Covid‐19 pandemic, was found to be a risk factor for hospitalization from Covid‐19. In this review, we also discuss the preclinical and mechanistic studies that have evaluated the role of androgens in SARS‐CoV‐2 infection and illness. Finally, long‐term consequences of Covid‐19 on male reproductive health are reviewed. SARS‐CoV‐2 virus is known to infiltrate testis and induce orchitis in men, but it is unclear if Covid‐19 leads to an increase in incidence of male hypogonadism.
Jezik:
Angleški jezik
Ključne besede:
Covid‐19
,
hypogonadism
,
SARS‐CoV‐2
,
testes
,
testosterone
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2024
Št. strani:
Str. 56-65
Številčenje:
Vol. 100, iss. 1
PID:
20.500.12556/RUL-159131
ISSN pri članku:
0300-0664
DOI:
10.1111/cen.14952
COBISS.SI-ID:
201676803
Datum objave v RUL:
01.07.2024
Število ogledov:
167
Število prenosov:
35
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Clinical endocrinology
Skrajšan naslov:
Clin. endocrinol.
Založnik:
Wiley
ISSN:
0300-0664
COBISS.SI-ID:
25230336
Licence
Licenca:
CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:
Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
COVID-19
,
hipogonadizem
,
SARS-CoV-2
,
moda
,
testosteron
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