Enhanced hemocompatibility and cytocompatibility of stainless steel

Benčina, Metka (author), Rawat, Niharika (author), Paul, Domen (author), Kovač, Janez (author), Lakota, Katja (author), Žigon, Polona (author), Kralj-Iglič, Veronika (author), Iglič, Aleš (author), Junkar, Ita (author)

The present study introduces an advanced surface modification approach combining electrochemical anodization and non-thermal plasma treatment, tailored for biomedical applications on stainless steel grade 316L (SS316L) surfaces. Nanopores with various diameters (100−300 nm) were synthesized with electrochemical anodization, and samples were further modified with non-thermal oxygen plasma. The surface properties of SS316L surfaces were examined by scanning electron microscopy, atomic force microscopy, X-ray photoemission spectroscopy, and Water contact angle measurements. It has been shown that a combination of electrochemical anodization and plasma treatment significantly alters the surface properties of SS316L and affects its interactions with blood platelets and human coronary cells. Optimal performance is attained on the anodized specimen featuring pores within the 150−300 nm diameter range, subjected to subsequent oxygen plasma treatment; the absence of platelet adhesion was observed. At the same time, the sample demonstrated good endothelialization and a reduction in smooth muscle cell adhesion compared to the untreated SS316L and the sample with smaller pores (100−150 nm). This novel surface modification strategy has significant implications for improving biocompatibility and performance of SS316L in biomedical applications.

• Language: English
• Keywords: surface modifications, electrochemical anodization, non-thermal plasma treatment, altered surface properties, blood platelets, human coronary stents, anatomy, anodization, cells, plasma, surface interactions
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FE - Faculty of Electrical Engineering; ZF - Faculty of Health Sciences; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: Str. 19566–19577
• Numbering: Vol. 9, iss. 17
• PID: 20.500.12556/RUL-156097
• UDC: 577
• ISSN on article: 2470-1343
• DOI: 10.1021/acsomega.4c01191
• COBISS.SI-ID: 193934339
• Publication date in RUL: 08.05.2024

Record is a part of a journal

• Title: ACS omega
• Shortened title: ACS omega
• Publisher: American Chemical Society
• ISSN: 2470-1343
• COBISS.SI-ID: 525873945

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.