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Potential medical use of fullerenols after two decades of oncology research
ID
Injac, Rade
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(888,68 KB)
MD5: 545F7FBB90BDA4C17DEAC7669476FAF9
URL - Izvorni URL, za dostop obiščite
https://journals.sagepub.com/doi/10.1177/15330338231201515
Galerija slik
Izvleček
Fullerenes are carbon molecules that are found in nature in various forms. They are composed of hexagonal and pentagonal rings that create closed structures. Almost 4 decades ago, fullerenes were identified in the form of C$_{60}$ and C$_{70}$, and following the award of the Nobel Prize in Chemistry for this discovery in 1996, many laboratories started working on their water-soluble derivatives that could be used in different industries, including pharmaceutical industries. One of the first fullerene forms that was the focus of different research groups was fullerenol, C$_{60}$(OH)$_n$ (n = 2-44). Both in-vitro and in-vivo studies have shown that polyhydroxylate fullerene derivatives can potentially be used as either antioxidative agents or cytostatics (depending on their co-administration, forms, and concentration/dose) in biological systems. The current review aimed to present a critical view of the potential applications and limitations of fullerenols in oncology, as understood from the past 2 decades of research.
Jezik:
Angleški jezik
Ključne besede:
fullerenol
,
toxicity
,
oxidative stress
,
organ protection
,
cytostatics
,
oncology
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
21 str.
Številčenje:
Vol. 22
PID:
20.500.12556/RUL-154171
UDK:
621.3:61
ISSN pri članku:
1533-0346
DOI:
10.1177/15330338231201515
COBISS.SI-ID:
169696003
Datum objave v RUL:
29.01.2024
Število ogledov:
332
Število prenosov:
21
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Objavi na:
Gradivo je del revije
Naslov:
Technology in cancer research and treatment
Založnik:
SAGE
ISSN:
1533-0346
COBISS.SI-ID:
2235761
Licence
Licenca:
CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:
Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.
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