The trajectory of sarcopenia following diagnosis of prostate cancer : a systematic review and meta-analysis

Kovač-Blaž, Milena (author), Pavlin, Tina (author), Čavka, Luka (author), Ribnikar, Domen (author), Spazzapan, Simon (author), Templeton, Arnoud J. (author), Šeruga, Boštjan (author)

Introduction: Sarcopenia is a common skeletal muscle disorder in older people. Here we explore the prevalence of sarcopenia and its impact on men with prostate cancer. Materials and Methods: We searched PubMed, Embase, and Web of Science databases for relevant studies with an explicit definition of sarcopenia in men with prostate cancer which were published between years 2000 and 2022. Prevalence of sarcopenia and its association with time to biochemical recurrence (BCR), progression-free survival (PFS), non-cancer mortality, overall survival (OS), and treatment-related complications in men with prostate cancer were explored. The summary prevalence, hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated. Results: A total of 24 studies comprising 3,616 patients with early and advanced prostate cancer were included. The prevalence of sarcopenia and sarcopenic obesity was 43.8% (95% CI 19.2%–68.5%) and 24.0% (95% CI 5.0%–43.1%), respectively. Sarcopenia was not associated with a shorter time to BCR (HR 0.89, 95% CI 0.64–1.23, p = 0.48), a shorter PFS (HR 1.20, 95% CI 0.73–1.97, p = 0.48), or a shorter OS (HR 1.29, 95% CI 0.90–1.85, p = 0.16). In contrast, sarcopenia was significantly associated with a higher non-cancer mortality (HR 1.85, 95% CI 1.23–2.80, p = 0.003). In four out of five studies eligible for assessment, sarcopenia was not associated with an increased risk of treatment-related complications. Discussion: Sarcopenia increases the risk of death from other causes in men with prostate cancer. Patients with prostate cancer should be assessed and managed for sarcopenia in everyday clinical practice.

• Language: English
• Keywords: sarcopenia, sarcopenic obesity, prostate cancer, meta-analysis
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 10 str.
• Numbering: Vol. 14, iss. 7, art. 101594
• PID: 20.500.12556/RUL-153026
• UDC: 616.6
• ISSN on article: 1879-4068
• DOI: 10.1016/j.jgo.2023.101594
• COBISS.SI-ID: 160455683
• Publication date in RUL: 14.12.2023

Record is a part of a journal

• Title: Journal of geriatric oncology
• Publisher: Elsevier
• ISSN: 1879-4068
• COBISS.SI-ID: 519697433

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: sarkopenija, sarkopenična debelost, rak prostate

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0321
• Name: Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrstah raka