20.500.12556/RUL-153026 The trajectory of sarcopenia following diagnosis of prostate cancer a systematic review and meta-analysis Introduction: Sarcopenia is a common skeletal muscle disorder in older people. Here we explore the prevalence of sarcopenia and its impact on men with prostate cancer. Materials and Methods: We searched PubMed, Embase, and Web of Science databases for relevant studies with an explicit definition of sarcopenia in men with prostate cancer which were published between years 2000 and 2022. Prevalence of sarcopenia and its association with time to biochemical recurrence (BCR), progression-free survival (PFS), non-cancer mortality, overall survival (OS), and treatment-related complications in men with prostate cancer were explored. The summary prevalence, hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated. Results: A total of 24 studies comprising 3,616 patients with early and advanced prostate cancer were included. The prevalence of sarcopenia and sarcopenic obesity was 43.8% (95% CI 19.2%–68.5%) and 24.0% (95% CI 5.0%–43.1%), respectively. Sarcopenia was not associated with a shorter time to BCR (HR 0.89, 95% CI 0.64–1.23, p = 0.48), a shorter PFS (HR 1.20, 95% CI 0.73–1.97, p = 0.48), or a shorter OS (HR 1.29, 95% CI 0.90–1.85, p = 0.16). In contrast, sarcopenia was significantly associated with a higher non-cancer mortality (HR 1.85, 95% CI 1.23–2.80, p = 0.003). In four out of five studies eligible for assessment, sarcopenia was not associated with an increased risk of treatment-related complications. Discussion: Sarcopenia increases the risk of death from other causes in men with prostate cancer. Patients with prostate cancer should be assessed and managed for sarcopenia in everyday clinical practice. sarcopenia sarcopenic obesity prostate cancer meta-analysis sarkopenija sarkopenična debelost rak prostate true false true Angleški jezik Slovenski jezik Članek v reviji 2023-12-14 15:13:39 2023-12-14 15:13:43 2023-12-15 03:49:27 0000-00-00 00:00:00 2023 0 0 10 str. iss. 7, art. 101594 Vol. 14 Sep. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.6 1879-4068 10.1016/j.jgo.2023.101594 160455683 1-s2.0-S1879406823001911-main.pdf 1-s2.0-S1879406823001911-main.pdf 1 19E6E7D7F3C518FF30B514F6C1B12402 4ab1c892fefcc9a2a32a3718eaffc195a50846d1c6f61f8ba4010de546a959b3 60cbfc11-9a8b-11ee-91f8-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178814 https://www.sciencedirect.com/science/article/pii/S1879406823001911 0 365316a6-9a8b-11ee-91f8-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178813 Medicinska fakulteta 0 0 0