The correlation between the triglyceride-glucose index and coagulation markers in patients with recent acute myocardial infarction

Košuta, Daniel (author), Novaković, Marko (author), Božič, Mojca (author), Jug, Borut (author)

Background: Metabolic abnormalities and hypercoagulability seem to have an important predictive role in patients with coronary artery disease (CAD). The triglyceride-glucose (TyG) index has emerged as a good marker for metabolic syndrome with predictive value for cardiovascular events. Overall haemostatic potential (OHP) is a reliable global haemostatic essay to identify hypercoagulability in CAD patients. The aim of our study was therefore to evaluate a possible correlation between the TyG index and haemostatic derangements in patients with CAD. Methods: Consecutive patients referred for the first follow-up visit after acute myocardial infarction between December 1, 2018, and March 31, 2020, and did not meet exclusion criteria were included. We determined OHP, overall coagulation potential (OCP), overall fibrinolytic potential (OFP), fibrinogen, D-dimer, and von Willebrand factor from peripheral blood samples. The TyG index was calculated with the previously described and validated formula. Linear regression models were constructed for the multivariate analysis. Results: A total of 117 patients (mean age 56 ± 10 years, 20% women) were included. A correlation was found between TyG index and OCP (r = 0.229, p = 0.026), TyG index and OHP (r = 0.202, p = 0.050), and TyG index and fibrinogen (r = 0.271, p = 0.005). In the multivariate model which accounted for sex, age, and BMI, the correlation between TyG index and OCP (R$^2$ 0.108; ANOVA for regression p = 0.035; beta 2.08 [0.79-4.01], p = 0.042) and between TyG index and fibrinogen (R$^2$ 0.11; ANOVA for regression p = 0.015; beta 0.35 [0.08-0.62], p = 0.012) emerged as statistically significant. Conclusion: The TyG index, a marker of metabolic syndrome, has a strong correlation with a hypercoagulability state in CAD, as determined by the OCP and higher fibrinogen levels. Our findings suggest that metabolic syndrome may be an important driver of atherothrombotic risk in patients with CAD.

• Language: English
• Keywords: coronary artery disease, acute myocardial infarction, triglyceride-glucose index
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine; FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 6 str.
• Numbering: Vol. 2022, art. 6206802
• PID: 20.500.12556/RUL-152337
• UDC: 616.1
• ISSN on article: 1875-8630
• DOI: 10.1155/2022/6206802
• COBISS.SI-ID: 141952515
• Publication date in RUL: 21.11.2023

Record is a part of a journal

• Title: Disease markers
• Publisher: Hindawi
• ISSN: 1875-8630
• COBISS.SI-ID: 516120089

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: bolezen koronarnih arterij, akutni miokardni infarkt, indeks trigliceridov in glukoze

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: University Medical Centre Ljubljana, Intern tertiary grant

• Funder: ARRS - Slovenian Research Agency
• Project number: V3-2104
• Name: Sekundarna preventiva in kakovosti oskrbe po srčnem infarktu v slovenskih bolnišnicah ter analiza vpliva epidemije covid-19 na obravnavo aterosklerotične bolezni