20.500.12556/RUL-152337 The correlation between the triglyceride-glucose index and coagulation markers in patients with recent acute myocardial infarction Background: Metabolic abnormalities and hypercoagulability seem to have an important predictive role in patients with coronary artery disease (CAD). The triglyceride-glucose (TyG) index has emerged as a good marker for metabolic syndrome with predictive value for cardiovascular events. Overall haemostatic potential (OHP) is a reliable global haemostatic essay to identify hypercoagulability in CAD patients. The aim of our study was therefore to evaluate a possible correlation between the TyG index and haemostatic derangements in patients with CAD. Methods: Consecutive patients referred for the first follow-up visit after acute myocardial infarction between December 1, 2018, and March 31, 2020, and did not meet exclusion criteria were included. We determined OHP, overall coagulation potential (OCP), overall fibrinolytic potential (OFP), fibrinogen, D-dimer, and von Willebrand factor from peripheral blood samples. The TyG index was calculated with the previously described and validated formula. Linear regression models were constructed for the multivariate analysis. Results: A total of 117 patients (mean age 56 ± 10 years, 20% women) were included. A correlation was found between TyG index and OCP (r = 0.229, p = 0.026), TyG index and OHP (r = 0.202, p = 0.050), and TyG index and fibrinogen (r = 0.271, p = 0.005). In the multivariate model which accounted for sex, age, and BMI, the correlation between TyG index and OCP (R$^2$ 0.108; ANOVA for regression p = 0.035; beta 2.08 [0.79-4.01], p = 0.042) and between TyG index and fibrinogen (R$^2$ 0.11; ANOVA for regression p = 0.015; beta 0.35 [0.08-0.62], p = 0.012) emerged as statistically significant. Conclusion: The TyG index, a marker of metabolic syndrome, has a strong correlation with a hypercoagulability state in CAD, as determined by the OCP and higher fibrinogen levels. Our findings suggest that metabolic syndrome may be an important driver of atherothrombotic risk in patients with CAD. coronary artery disease acute myocardial infarction triglyceride-glucose index bolezen koronarnih arterij akutni miokardni infarkt indeks trigliceridov in glukoze true false true Angleški jezik Slovenski jezik Članek v reviji 2023-11-21 09:38:45 2023-11-21 09:38:50 2023-11-22 03:38:21 0000-00-00 00:00:00 2022 0 0 6 str. Vol. 2022, art. 6206802 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1875-8630 10.1155/2022/6206802 141952515 RAZ_Kosuta_Daniel_2022.pdf RAZ_Kosuta_Daniel_2022.pdf 1 E800078356C907FCB24DAE4BFE80C247 6c36f68e6051d4c7c8cd9f90d581f840220c04d8223cf2942801a994e9266be7 6575b760-8849-11ee-8d2e-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=177795 https://www.hindawi.com/journals/dm/2022/6206802/ 0 8a16c3f4-8849-11ee-8d2e-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=177796 Medicinska fakulteta Fakulteta za farmacijo 0 0 0