Reakcije L-tiroksina z nikotinamidom in 3-hidroksipiridinom

Račič, Luka (author), Perdih, Franc (mentor)

V sklopu diplomske naloge sem preverjal tvorbo kokristalov oz. soli različnih organskih spojin z L-tiroksinom. Izbrani reagenti so vsebovali različna akceptorska mesta halogenskih vezi. Testiral sem topnost izhodnih reagentov v topilih H2O, DMF in MeOH ter nato izvedel reakcijo teh reagentov z L-tiroksinom v izbranih topilih ter poskušal tvoriti kristale s počasnim izhlapevanjem topil iz steklenih kivet z reakcijsko raztopino. Tvorjene produkte in reagente sem nato analiziral z uporabo rentgenske praškovne difrakcije. V nalogi sem se osredotočil predvsem na reakcije z nikotinamidom in 3-hidroksipiridinom, ki sta dala najboljše rezultate.

• Language: Slovenian
• Keywords: halogenska vez, kokristal, rentgenska praškovna analiza, L-tiroksin
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2023
• PID: 20.500.12556/RUL-149687
• COBISS.SI-ID: 171489795
• Publication date in RUL: 08.09.2023

Secondary language

• Language: English
• Title: Reactions of L-thyroxine with nicotinamide and 3-hydroxypyridine

Abstract

As part of my diploma thesis, I examined the formation of cocrystals or salts of various organic compounds with L-thyroxine. The selected reagents contained different halogen bond acceptor sites. I tested the solubility of the starting reagents in H2O, DMF and MeOH and then reacted these reagents with L-thyroxine in the selected solvents and attempted to form crystals by slow evaporation of the solvents from glass cuvettes containing the reaction solution. The products and reagents formed were then analysed by X-ray powder diffraction. In this thesis I focused mainly on the reactions with nicotinamide and 3-hydroxypyridine, which gave the best results.

• Keywords: halogen bond, cocrystal, X-ray powder analysis, L-thyroxine