20.500.12556/RUL-149687 Reakcije L-tiroksina z nikotinamidom in 3-hidroksipiridinom Reactions of L-thyroxine with nicotinamide and 3-hydroxypyridine V sklopu diplomske naloge sem preverjal tvorbo kokristalov oz. soli različnih organskih spojin z L-tiroksinom. Izbrani reagenti so vsebovali različna akceptorska mesta halogenskih vezi. Testiral sem topnost izhodnih reagentov v topilih H2O, DMF in MeOH ter nato izvedel reakcijo teh reagentov z L-tiroksinom v izbranih topilih ter poskušal tvoriti kristale s počasnim izhlapevanjem topil iz steklenih kivet z reakcijsko raztopino. Tvorjene produkte in reagente sem nato analiziral z uporabo rentgenske praškovne difrakcije. V nalogi sem se osredotočil predvsem na reakcije z nikotinamidom in 3-hidroksipiridinom, ki sta dala najboljše rezultate. As part of my diploma thesis, I examined the formation of cocrystals or salts of various organic compounds with L-thyroxine. The selected reagents contained different halogen bond acceptor sites. I tested the solubility of the starting reagents in H2O, DMF and MeOH and then reacted these reagents with L-thyroxine in the selected solvents and attempted to form crystals by slow evaporation of the solvents from glass cuvettes containing the reaction solution. The products and reagents formed were then analysed by X-ray powder diffraction. In this thesis I focused mainly on the reactions with nicotinamide and 3-hydroxypyridine, which gave the best results. halogenska vez kokristal rentgenska praškovna analiza L-tiroksin halogen bond cocrystal X-ray powder analysis L-thyroxine true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2023-09-08 10:40:00 2023-09-08 10:40:03 2023-11-09 12:11:31 0000-00-00 00:00:00 2023 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 23056 171489795 Racic_Luka_-_Reakcije_L-tiroksina_z_nikotinamidom_in_3-hidroksipiridinom.pdf Racic_Luka_-_Reakcije_L-tiroksina_z_nikotinamidom_in_3-hidroksipiridinom.pdf 1 A20F2DE46C7F56CB2301CAE97F22B3FE 210087ff6396ec3eb6bfda8e1343bc0bcf74ad2fce7b055782eff194a0e213d2 4f8f09c7-4e23-11ee-9323-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=174181 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0