Fetal death from SARS-CoV-2 mediated acute placental failure

Kosič, Nadja (author), Luzar, Boštjan (author), Pečlin, Polona (author), Druškovič, Mirjam (author), Resman Rus, Katarina (author), Avšič-Županc, Tatjana (author), Premru-Sršen, Tanja (author)

Introduction: We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure. Methods: Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus. Results: Histologic changes in the placenta correlate with SARS-CoV-2 infection. Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2. Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant. Discussion: Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive. It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. Most of the cases described with fetal death occurred in the third trimester.

• Language: English
• Keywords: Covid-19, Delta variant, fetal death, early embryo implantation, SARS-CoV-2, placenta
• Work type: Article
• Typology: 1.03 - Other scientific articles
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 5 str.
• Numbering: Vol. 158, art. 103958
• PID: 20.500.12556/RUL-148646
• UDC: 618.1
• ISSN on article: 1872-7603
• DOI: 10.1016/j.jri.2023.103958
• COBISS.SI-ID: 154593539
• Publication date in RUL: 28.08.2023

Record is a part of a journal

• Title: Journal of reproductive immunology
• Publisher: Elsevier
• ISSN: 1872-7603
• COBISS.SI-ID: 23066885

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: covid-19, smrt ploda, različica delta