Fetal death from SARS-CoV-2 mediated acute placental failure

Kosič, Nadja (avtor), Luzar, Boštjan (avtor), Pečlin, Polona (avtor), Druškovič, Mirjam (avtor), Resman Rus, Katarina (avtor), Avšič-Županc, Tatjana (avtor), Premru-Sršen, Tanja (avtor)

Introduction: We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure. Methods: Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus. Results: Histologic changes in the placenta correlate with SARS-CoV-2 infection. Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2. Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant. Discussion: Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive. It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. Most of the cases described with fetal death occurred in the third trimester.

• Jezik: Angleški jezik
• Ključne besede: Covid-19, Delta variant, fetal death, early embryo implantation, SARS-CoV-2, placenta
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.03 - Kratki znanstveni prispevek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 5 str.
• Številčenje: Vol. 158, art. 103958
• PID: 20.500.12556/RUL-148646
• UDK: 618.1
• ISSN pri članku: 1872-7603
• DOI: 10.1016/j.jri.2023.103958
• COBISS.SI-ID: 154593539
• Datum objave v RUL: 28.08.2023

Gradivo je del revije

• Naslov: Journal of reproductive immunology
• Založnik: Elsevier
• ISSN: 1872-7603
• COBISS.SI-ID: 23066885

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: covid-19, smrt ploda, različica delta