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Adverse drug reactions in the ambulatory internal patients at the emergency department : focus on causality assessment and drug-drug interactions
ID
Dobravc Verbič, Matej
(
Avtor
),
ID
Brvar, Miran
(
Avtor
),
ID
Kerec Kos, Mojca
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(530,80 KB)
MD5: 2CD38E8AF3ACA67257B8F27ECB19CD57
URL - Izvorni URL, za dostop obiščite
https://sciendo.com/article/10.2478/acph-2023-0013
Galerija slik
Izvleček
A non-interventional retrospective study in ambulatory patients was conducted at the emergency department of the Division of internal medicine. In 2 months, 266 suspected adverse drug reactions (ADRs) were identified in 224/3453 patients (6.5 %). In 158/3453 patients (4.6 %), an ADR was the reason for emergency department visit and in 49 patients (1.4 %), ADRs led to hospitalisation. A causality assessment algorithm was developed, which included Naranjo algorithm and levels of ADR recognition by the treating physician and the investigators. Using this algorithm, 63/266 ADRs (23.7 %) were classified as “certain”, whereas using solely the Naranjo score calculation, only 19/266 ADRs (7.1 %) were assessed as “probable” or “certain”, and the rest of ADRs (namely, 247/266 = 92.9 %) were assessed as “possible”. There were 116/266 (43.6 %) ADRs related to potential drug-drug interactions (DDIs), stated in at least one of the literature sources used. Based on the causality relationship, the rate of the clinically expressed DDIs was 19.0 %, or 12/63 “certain” ADR cases. Of these, 10 cases presented serious DDI-related ADRs. In summary, ADR causality assessment based exclusively on Naranjo algorithm demonstrated low sensitivity at an ambulatory emergency setting. Additional clinical judgment, including the opinion of the treating physician, proved necessary to avoid under-rating of the causality relationship, and enabled the determination of clinically expressed DDIs.
Jezik:
Angleški jezik
Ključne besede:
adverse drug reactions
,
drug interactions
,
causality assessment
,
emergency department
,
ambulatory patients
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
Str. 195-210
Številčenje:
Vol. 73, iss. 2
PID:
20.500.12556/RUL-148362
UDK:
615.065:616-08-056.24
ISSN pri članku:
1846-9558
DOI:
10.2478/acph-2023-0013
COBISS.SI-ID:
139850755
Avtorske pravice:
Licenca Creative Commons (CC BY-NC-ND) je z ikono navedena na pristajalni strani članka (glej izvorni URL). Ta licenca je navedena tudi v zapisu za revijo Acta pharmaceutica v DOAJ (
https://doaj.org/toc/1846-9558
). (Datum opombe 25. 8. 2023)
Datum objave v RUL:
18.08.2023
Število ogledov:
778
Število prenosov:
52
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Objavi na:
Gradivo je del revije
Naslov:
Acta pharmaceutica
Skrajšan naslov:
Acta pharm.
Založnik:
Croatian Pharmaceutical Society
ISSN:
1846-9558
COBISS.SI-ID:
3817585
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
neželeni učinki zdravil
,
interakcije zdravil
,
ocena vzročnosti
,
urgentni oddelek
,
ambulantni bolniki
,
zdravila
,
neželeni učinki
,
ambulantno zdravljenje
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0019
Naslov:
Aplikativna in bazična fiziologija in patofiziologija v medicini
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0189
Naslov:
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih
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