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Antibacterial and degradation properties of dialdehyded and aminohexamethylated nanocelluloses
ID
Kokol, Vanja
(
Author
),
ID
Novak, Sara
(
Author
),
ID
Kononenko, Veno
(
Author
),
ID
Kos, Monika
(
Author
),
ID
Vivod, Vera
(
Author
),
ID
Gunde-Cimerman, Nina
(
Author
),
ID
Drobne, Damjana
(
Author
)
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https://www.sciencedirect.com/science/article/pii/S014486172300067X
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Abstract
Dialdehyde cellulose nanofibrils (CNF) and nanocrystals (CNC) were prepared via periodate oxidation (CNF/CNC-ox) and subsequently functionalized with hexamethylenediamine (HMDA) via a Schiff-base reaction, resulting in partially crosslinked micro-sized (0.5–10 μm) particles (CNF/CNC-ox-HMDA) with an aggregation and sedimentation tendency in an aqueous media, as assessed by Dynamic Light Scattering and Scanning Electron Microscopy. The antibacterial efficacy, aquatic in vivo (to Daphnia magna) and human in vitro (to A594 lung cells) toxicities, and degradation profiles in composting soil of all forms of CNF/CNC were assessed to define their safety profile. CNF/CNC-ox-HMDA exhibited higher antibacterial activity than CNF/CNC-ox and higher against Gram-positive S. aureus than Gram-negative E. coli, yielding a bacteria reduction of >90 % after 24 h of exposure at the minimum (≤2 mg/mL), but potentially moderately/aquatic and low/human toxic concentrations (≥50 mg/L). The presence of anionic, un/protonated amino-hydrophobized groups in addition to unconjugated aldehydes of hydrodynamically smaller (<1 μm) CNC-ox-HMDA increased the reduction of both bacteria to log 9 at ≥4 mg/mL and their bactericidal activity. While only CNF/CNC-ox can be considered as biosafe and up to >80 % biodegradable within 24 weeks, this process was inhibited for the CNF/CNC-ox-HMDA. This indicated their different stability, application and disposal after use (composting vs. recycling).
Language:
English
Keywords:
cellulose nanofibrils
,
cellulose nanocrystals
,
surface modification
,
antibacterial activity
,
toxicity
,
biodegradability
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
BF - Biotechnical Faculty
Publication status:
Published
Publication version:
Version of Record
Year:
2023
Number of pages:
16 str.
Numbering:
Vol. 311, art. 120603
PID:
20.500.12556/RUL-148282
UDC:
677.46:620.3
ISSN on article:
1879-1344
DOI:
10.1016/j.carbpol.2023.120603
COBISS.SI-ID:
139361027
Publication date in RUL:
09.08.2023
Views:
407
Downloads:
37
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Record is a part of a journal
Title:
Carbohydrate polymers
Shortened title:
Carbohydr. polym.
Publisher:
Elsevier
ISSN:
1879-1344
COBISS.SI-ID:
130008067
Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Secondary language
Language:
Slovenian
Keywords:
celulozni nanofibrili
,
celulozni nanokristali
,
modifikacija površine
,
antibakterijsko delovanje
,
toksičnost
,
biorazgradljivost
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
J2-1719
Name:
Strukturne in površinske lastnosti vlakninskih membran za čiščenje in kromatografsko separacijo biomakromolekul
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0424
Name:
Dizajn novih lastnosti (nano)materialov & aplikacije
Funder:
ARRS - Slovenian Research Agency
Project number:
P4-0432
Name:
Morska in mikrobna biotehnologija
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0198
Name:
Molekularno-biološke raziskave mikroorganizmov
Funder:
ARRS - Slovenian Research Agency
Project number:
I0-0022
Name:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
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