20.500.12556/RUL-148282 Antibacterial and degradation properties of dialdehyded and aminohexamethylated nanocelluloses Dialdehyde cellulose nanofibrils (CNF) and nanocrystals (CNC) were prepared via periodate oxidation (CNF/CNC-ox) and subsequently functionalized with hexamethylenediamine (HMDA) via a Schiff-base reaction, resulting in partially crosslinked micro-sized (0.5–10 μm) particles (CNF/CNC-ox-HMDA) with an aggregation and sedimentation tendency in an aqueous media, as assessed by Dynamic Light Scattering and Scanning Electron Microscopy. The antibacterial efficacy, aquatic in vivo (to Daphnia magna) and human in vitro (to A594 lung cells) toxicities, and degradation profiles in composting soil of all forms of CNF/CNC were assessed to define their safety profile. CNF/CNC-ox-HMDA exhibited higher antibacterial activity than CNF/CNC-ox and higher against Gram-positive S. aureus than Gram-negative E. coli, yielding a bacteria reduction of >90 % after 24 h of exposure at the minimum (≤2 mg/mL), but potentially moderately/aquatic and low/human toxic concentrations (≥50 mg/L). The presence of anionic, un/protonated amino-hydrophobized groups in addition to unconjugated aldehydes of hydrodynamically smaller (<1 μm) CNC-ox-HMDA increased the reduction of both bacteria to log 9 at ≥4 mg/mL and their bactericidal activity. While only CNF/CNC-ox can be considered as biosafe and up to >80 % biodegradable within 24 weeks, this process was inhibited for the CNF/CNC-ox-HMDA. This indicated their different stability, application and disposal after use (composting vs. recycling). cellulose nanofibrils cellulose nanocrystals surface modification antibacterial activity toxicity biodegradability celulozni nanofibrili celulozni nanokristali modifikacija površine antibakterijsko delovanje toksičnost biorazgradljivost true false true Angleški jezik Slovenski jezik Članek v reviji 2023-08-09 14:20:05 2023-08-09 14:20:07 2023-08-10 03:36:57 0000-00-00 00:00:00 2023 0 0 16 str. Vol. 311, art. 120603 Jul. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 677.46:620.3 1879-1344 10.1016/j.carbpol.2023.120603 139361027 1-s2.0-S014486172300067X-main.pdf 1-s2.0-S014486172300067X-main.pdf 1 1DF309CC9118640B918D82AF4334815C a9bdc42034a55b300131688061fdfd85eb2b84039a5abc455416ca4050c5f956 4592a266-36af-11ee-aeaf-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172370 https://www.sciencedirect.com/science/article/pii/S014486172300067X 0 25ebef7e-36af-11ee-aeaf-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172369 Biotehniška fakulteta 0 0 0