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Is obstructive sleep apnea a circadian rhythm disorder?
ID
Šmon, Julija
(
Avtor
),
ID
Kočar, Eva
(
Avtor
),
ID
Pintar, Tadeja
(
Avtor
),
ID
Dolenc-Grošelj, Leja
(
Avtor
),
ID
Rozman, Damjana
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(2,09 MB)
MD5: BCD10025E66C98CEA4AAEACFA4226637
URL - Izvorni URL, za dostop obiščite
https://onlinelibrary.wiley.com/doi/10.1111/jsr.13875
Galerija slik
Izvleček
Obstructive sleep apnea is the most common sleep-related breathing disorder worldwide and remains underdiagnosed. Its multiple associated comorbidities contribute to a decreased quality of life and work performance as well as an increased risk of death. Standard treatment seems to have limited effects on cardiovascular and metabolic aspects of the disease, emphasising the need for early diagnosis and additional therapeutic approaches. Recent evidence suggests that the dysregulation of circadian rhythms, processes with endogenous rhythmicity that are adjusted to the environment through various cues, is involved in the pathogenesis of comorbidities. In patients with obstructive sleep apnea, altered circadian gene expression patterns have been demonstrated. Obstructive respiratory events may promote circadian dysregulation through the effects of sleep disturbance and intermittent hypoxia, with subsequent inflammation and disruption of neural and hormonal homeostasis. In this review, current knowledge on obstructive sleep apnea, circadian rhythm regulation, and circadian rhythm sleep disorders is summarised. Studies that connect obstructive sleep apnea to circadian rhythm abnormalities are critically evaluated. Furthermore, pathogenetic mechanisms that may underlie this association, most notably hypoxia signalling, are presented. A bidirectional relationship between obstructive sleep apnea and circadian rhythm dysregulation is proposed. Approaching obstructive sleep apnea as a circadian rhythm disorder may prove beneficial for the development of new, personalised diagnostic, therapeutic and prognostic tools. However, further studies are needed before the clinical approach to obstructive sleep apnea includes targeting the circadian system.
Jezik:
Angleški jezik
Ključne besede:
obstructive sleep apnea
,
breathing disorder
,
circadian rhythms
,
chronotherapy
,
comorbidities
,
gene expression
,
hypoxia
,
molecular clock
,
sleep disorders
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
20 str.
Številčenje:
Vol. 32, iss. 4, art. e13875
PID:
20.500.12556/RUL-148261
UDK:
616.2
ISSN pri članku:
1365-2869
DOI:
10.1111/jsr.13875
COBISS.SI-ID:
145368323
Datum objave v RUL:
08.08.2023
Število ogledov:
892
Število prenosov:
33
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Journal of sleep research
Skrajšan naslov:
J. sleep res.
Založnik:
Wiley, European Sleep Research Society
ISSN:
1365-2869
COBISS.SI-ID:
517774873
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
obstruktivna apneja v spanju
,
motnja dihanja
,
cirkadiani ritem
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0338
Naslov:
Fiziološki mehanizmi nevroloških motenj in bolezni
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0390
Naslov:
Funkcijska genomika in biotehnologija za zdravje
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
IP-022 MRIC-CFGBC
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Program financ.:
Young researchers
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