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A comparative study of lipid-based drug delivery systems with different microstructure for combined dermal administration of antioxidant vitamins
ID
Vitek, Mercedes
(
Avtor
),
ID
Gosenca Matjaž, Mirjam
(
Avtor
),
ID
Roškar, Robert
(
Avtor
),
ID
Gašperlin, Mirjana
(
Avtor
),
ID
Zvonar Pobirk, Alenka
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(2,54 MB)
MD5: 1A3598B7E0EDAC9AE4FA801610E12644
URL - Izvorni URL, za dostop obiščite
https://www.tandfonline.com/doi/full/10.1080/01932691.2022.2037437
Galerija slik
Izvleček
Antioxidant vitamins have been proven to be highly efficient in treatment of skin impaired by oxidative stress, but challenges regarding stability and skin penetration limit their therapeutic effect. Lipid-based drug delivery systems offer great potential for overcoming these drawbacks. This work aimed to identify the most promising system for combined antioxidant therapy. A comparative assessment of several systems, containing the same ingredients but differing in their microstructure, was therefore performed. Namely, microemulsions (MEs) of both types (W/O and O/W) and lyotropic liquid crystals (LLCs), simultaneously loaded with vitamin C or ascorbyl palmitate and vitamin E, were assessed. Stability, antioxidant capacity (DPPH assay), and release (Franz diffusion cells) of the vitamins incorporated was examined. The results obtained were supported with the systems’ thermal and rheological (rotational and oscillatory tests) evaluation. In addition, biological acceptability (MTS assay) of the systems studied was investigated. The findings demonstrate that the microstructure of MEs and LLCs studied has a decisive impact on the stability, antioxidant activity, and release of the vitamins incorporated. The highest stability was preserved in LLCs for both pairings, with vitamins C and E being a more stable combination. LLCs also provided suitable vitamins’ antioxidant activity and release characteristics. In addition, the system exhibited preferable rheological features for dermal administration. Furthermore, cytotoxicity studies on a keratinocyte cell line demonstrated the highest biocompatibility for LCCs with the cell proliferation being greater than 85%. In conclusion, LLCs were confirmed as the most favorable lipid-based drug delivery system for combined antioxidant treatment.
Jezik:
Angleški jezik
Ključne besede:
lyotropic liquid crystals
,
microemulsions
,
vitamin C
,
ascorbyl palmitate
,
vitamin E
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
Str. 1711–1724
Številčenje:
Vol. 44, no. 9
PID:
20.500.12556/RUL-148029
UDK:
66.094.3.097.8+612.015
ISSN pri članku:
1532-2351
DOI:
10.1080/01932691.2022.2037437
COBISS.SI-ID:
98150147
Datum objave v RUL:
26.07.2023
Število ogledov:
458
Število prenosov:
37
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Objavi na:
Gradivo je del revije
Naslov:
Journal of dispersion science and technology
Skrajšan naslov:
J. dispers. sci. technol.
Založnik:
Taylor & Francis
ISSN:
1532-2351
COBISS.SI-ID:
520954137
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
tekoči kristali
,
mikroemulzije
,
vitamin C
,
askorbil palmitat
,
vitamin E
,
oksidativni stres
,
antioksidanti
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0189
Naslov:
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih
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