A review on immunomodulatory effects of BPA analogues

Kodila, Anja (author), Franko, Nina (author), Sollner Dolenc, Marija (author)

Bisphenol A (BPA) is a known endocrine disruptor found in many consumer products that humans come into contact with on a daily basis. Due to increasing concerns about the safety of BPA and the introduction of new legislation restricting its use, industry has responded by adopting new, less studied BPA analogues that have similar polymer-forming properties. Some BPA analogues have already been shown to exhibit effects similar to BPA, for example, contributing to endocrine disruption through agonistic or antagonistic behaviour at various nuclear receptors such as estrogen (ER), androgen (AR), glucocorticoid (GR), aryl hydrocarbon (AhR), and pregnane X receptor (PXR). Since the European Food Safety Authority (EFSA) issued a draft re-evaluation of BPA and drastically reduced the temporary tolerable daily intake (t-TDI) of BPA from 4 mg/kg body weight/day to 0.2 ng/kg body weight/day due to increasing concern about the toxic properties of BPA, including its potential to disrupt immune system processes, we conducted a comprehensive review of the immunomodulatory activity of environmentally abundant BPA analogues. The results of the review suggest that BPA analogues may affect both the innate and acquired immune systems and can contribute to various immune-mediated conditions such as hypersensitivity reactions, allergies, and disruption of the human microbiome.

• Language: English
• Keywords: BPA analogues, immunomodulation, immunotoxicology, endocrine disruptors, bisphenols
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: Str. 1831-1846
• Numbering: Vol. 97, iss. 7
• PID: 20.500.12556/RUL-147579
• UDC: 612.43:620.266.1
• ISSN on article: 0340-5761
• DOI: 10.1007/s00204-023-03519-y
• COBISS.SI-ID: 152772355
• Publication date in RUL: 07.07.2023

Record is a part of a journal

• Title: Archives of toxicology
• Shortened title: Arch. toxicol.
• Publisher: Springer Nature
• ISSN: 0340-5761
• COBISS.SI-ID: 562452

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: analogi BPA, imunotoksikologija, endokrini motilci, bisfenoli, hormonski motilci, imunomodulacija, toksikologija