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A review on immunomodulatory effects of BPA analogues
ID
Kodila, Anja
(
Author
),
ID
Franko, Nina
(
Author
),
ID
Sollner Dolenc, Marija
(
Author
)
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MD5: B08ADD8B3EC5593D1B2C79048D4012E8
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https://link.springer.com/article/10.1007/s00204-023-03519-y
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Abstract
Bisphenol A (BPA) is a known endocrine disruptor found in many consumer products that humans come into contact with on a daily basis. Due to increasing concerns about the safety of BPA and the introduction of new legislation restricting its use, industry has responded by adopting new, less studied BPA analogues that have similar polymer-forming properties. Some BPA analogues have already been shown to exhibit effects similar to BPA, for example, contributing to endocrine disruption through agonistic or antagonistic behaviour at various nuclear receptors such as estrogen (ER), androgen (AR), glucocorticoid (GR), aryl hydrocarbon (AhR), and pregnane X receptor (PXR). Since the European Food Safety Authority (EFSA) issued a draft re-evaluation of BPA and drastically reduced the temporary tolerable daily intake (t-TDI) of BPA from 4 mg/kg body weight/day to 0.2 ng/kg body weight/day due to increasing concern about the toxic properties of BPA, including its potential to disrupt immune system processes, we conducted a comprehensive review of the immunomodulatory activity of environmentally abundant BPA analogues. The results of the review suggest that BPA analogues may affect both the innate and acquired immune systems and can contribute to various immune-mediated conditions such as hypersensitivity reactions, allergies, and disruption of the human microbiome.
Language:
English
Keywords:
BPA analogues
,
immunomodulation
,
immunotoxicology
,
endocrine disruptors
,
bisphenols
Work type:
Article
Typology:
1.02 - Review Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2023
Number of pages:
Str. 1831-1846
Numbering:
Vol. 97, iss. 7
PID:
20.500.12556/RUL-147579
UDC:
612.43:620.266.1
ISSN on article:
0340-5761
DOI:
10.1007/s00204-023-03519-y
COBISS.SI-ID:
152772355
Publication date in RUL:
07.07.2023
Views:
463
Downloads:
56
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Record is a part of a journal
Title:
Archives of toxicology
Shortened title:
Arch. toxicol.
Publisher:
Springer Nature
ISSN:
0340-5761
COBISS.SI-ID:
562452
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
analogi BPA
,
imunotoksikologija
,
endokrini motilci
,
bisfenoli
,
hormonski motilci
,
imunomodulacija
,
toksikologija
Projects
Funder:
ARRS - Slovenian Research Agency
Funding programme:
Young researchers
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0208
Name:
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin
Funder:
EC - European Commission
Funding programme:
HE
Project number:
101057014
Name:
Partnership for the Assessment of Risks from Chemicals
Acronym:
PARC
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