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Discovery of a novel bat lyssavirus in a long-fingered bat (Myotis capaccinii) from Slovenia
ID Černe, Danijela (Author), ID Hostnik, Peter (Author), ID Toplak, Ivan (Author), ID Presetnik, Primož (Author), ID Maurer Wernig, Jedrt (Author), ID Kuhar, Urška (Author)

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Abstract
Lyssaviruses are the causative agents of rabies, a zoonotic, fatal disease that is thought to be ancestral to bats. In the last decade, the detection of bat associated lyssaviruses is increasing also in Europe. Within a retrospective bat associated lyssavirus surveillance study a total of 225 dead bats of 21 bat species were collected in Slovenia between 2012 and 2019 and tested by specific real-time RT-PCR method. The first lyssavirus positive sample in bats in Slovenia was detected using the real-time RT-PCR, the fluorescent antibody test, and next generation sequencing, while the rabies tissue culture inoculation test was unsuccessful due to sample degradation and storage conditions. The nearly complete genome of Divača bat lyssavirus from Slovenia consists of 11,871 nucleotides and reflects the characteristic gene organization known for lyssaviruses, encoding the five viral proteins. Phylogenetic analysis of Divača bat lyssavirus revealed that it belongs to phylogroup I lyssaviruses and is most closely related to Kotalahti bat lyssavirus (KBLV) with 87.20% nucleotide and 99.22% amino acid identity. Together with KBLV, Khujand virus, European bat lyssavirus 2, Bakeloh bat lyssavirus, and Aravan virus, Divača bat lyssavirus was detected in the genus Myotis suggesting its key role in the transmission and maintenance of certain lyssaviruses.

Language:English
Keywords:real-time polymerase chain reaction, lyssaviruses, bats, rabies virus, phylogenetic analysis, Europe, zoonoses, nucleotides, species delimitation
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:VF - Veterinary Faculty
Publication status:Published
Publication version:Version of Record
Year:2023
Number of pages:12 str.
Numbering:Vol. 17, iss. 6, art. e0011420
PID:20.500.12556/RUL-147544 This link opens in a new window
UDC:636.09.578
ISSN on article:1935-2735
DOI:10.1371/journal.pntd.0011420 This link opens in a new window
COBISS.SI-ID:157448451 This link opens in a new window
Publication date in RUL:07.07.2023
Views:452
Downloads:75
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Record is a part of a journal

Title:PLoS neglected tropical diseases
Shortened title:PLoS negl. trop. dis.
Publisher:PLOS
ISSN:1935-2735
COBISS.SI-ID:29974745 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Projects

Funder:Other - Other funder or multiple funders
Funding programme:Administration of the Republic of Slovenia for Food Safety, Veterinary Sector, and Plant Protection

Funder:ARRS - Slovenian Research Agency
Project number:P4-0092
Name:Zdravje živali, okolje in varna hrana

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